GENETICS OF HUMAN LUNG CANCER

人类肺癌的遗传学

• 批准号: 6290299
• 负责人: Joan Ellen Bailey-Wilson
• 金额: --
• 依托单位: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6290299
• 关键词: blood chemistry; cancer risk; clinical research; data collection methodology /evaluation; environmental contamination; family genetics; genetic mapping; genetic markers; genetic registry /resource /referral center; genotype; human data; human genetic material tag; linkage mapping; lung neoplasms; neoplasm /cancer genetics; blood chemistry; cancer risk; clinical research; data collection methodology /evaluation; environmental contamination; family genetics; genetic mapping; genetic markers; genetic registry /resource /referral center; genotype; human data; human genetic material tag; linkage mapping; lung neoplasms; neoplasm /cancer genetics

During this fiscal year, this project, originally begun when Dr. Bailey-Wilson was a Professor at Louisiana State University Medical Center, has been continued. Work accomplished in thisfiscal year has included screening of cases and collection of family data collection and blood and tissue samples. The purpose of this study is to identify a gene or genes that contribute to lung cancer susceptibility. The specific aims are to 1) collect family history and environmental risk factor data about lung cancer from lung cancer patients and their families and to also collect blood and tissue samples from a subset of the families that appear informative for linkage analysis; 2) genotype the biological samples for a genome wide set of marker loci; 3) perform a genome-wide linkage analysis to attempt to localize a lung cancer susceptibility locus (loci). In this fiscal year, family history and biologic samples have been collected from both new and previously studied families. Dr. Bailey-Wilson has been instrumental in founding the Genetic Epidemiology of Lung Cancer Consortium (GELCC) for the purpose of obtaining additional family data from a large group of collaborative investigators. Genotyping has been started on three of the most informative pedigrees collected thus far. Data collection is ongoing and expected to continue for several more years. Approval for a genome-wide scan of the GELCC pedigrees by the Center for Inherited Disease Research (CIDR) has been obtained this year, and the first set of families will be sent to CIDR in January, 2000. Approximately one- fifth of this set of families will be from the Louisiana data collection effort. As head of the GELCC Analysis committee, Dr. Bailey- Wilson will be in charge of the analyses of these data. - linkage, lung cancer, genetics, smoking, pedigrees, hereditary

在这个财政年度，该项目最初是在贝利·威尔森（Bailey-Wilson）博士担任路易斯安那州立大学医学中心的教授时开始的。在本年度完成的工作包括筛查病例和收集家庭数据的收集以及血液和组织样本。这项研究的目的是确定有助于肺癌易感性的基因或基因。具体目的是1）收集有关肺癌患者及其家人的肺癌的家族史和环境风险因素数据，并从一部分的家庭中收集血液和组织样本，这些家庭似乎有信息以进行连锁分析； 2）基因型的基因组广泛标记基因座的生物样品； 3）进行全基因组的连锁分析，以尝试定位肺癌易感性基因座（LOCI）。在这个财政年度，已经从新的和先前研究的家庭中收集了家族史和生物样品。 Bailey-Wilson博士在建立肺癌财团（GELCC）的遗传流行病学方面发挥了作用，目的是从大量合作研究者那里获得其他家庭数据。迄今为止收集的三种最有用的血统，已经开始了基因分型。数据收集正在进行中，预计将持续几年。今年已获得了遗传性疾病研究中心（CIDR）对GELCC血统的批准，并于2000年1月将第一组家庭发送给CIDR。大约五分之一的家庭将来自路易斯安那州的数据收集工作。作为GELCC分析委员会的负责人，Bailey-Wilson博士将负责这些数据的分析。 - 连锁，肺癌，遗传学，吸烟，谱系，遗传