Schizophrenia Liability Genes among African Americans

非裔美国人的精神分裂症责任基因

• 批准号: 6506484
• 负责人: Alberto B. SANTOS
• 金额: $ 63.32万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-18 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6506484
• 关键词: African American; clinical research; cooperative study; family genetics; gene expression; genetic susceptibility; genotype; human subject; linkage disequilibriums; medically underserved population; mental disorder diagnosis; patient oriented research; phenotype; quantitative trait loci; schizophrenia

DESCRIPTION (provided by applicant): It is now obvious that large samples are essential to make much headway on the genetics of schizophrenia (SCZ). To identify genes that underlie liability to SCZ, we will recruit a large and diverse sample of 1260 African- American families, primarily from the southeastern US, all of whom have at least one member diagnosed with SCZ. A substantial portion of this diverse set of families will contribute to standard Affected Sibling and Relative Pair linkage analysis and to Quantitative Trait Locus (QTL) analyses of neurocognitive traits; the entire sample will be used for admixture mapping in candidate regions of interest This project also lays the foundation for QTL analysis by examining genetic influences on cognitive abilities among persons affected by SCZ and their extended family members. This minority sample would be impossible to recruit without multiple participating sites using the same protocol. Eight institutional sites have teamed up under the Collaborative ROls for Clinical Studies of Mental Disorders to accomplish this goal. The collaboration marries expertise in diagnoses, neurocognitive assessments, family recruitment, and genetic analyses. Substantial samples and refined, multivariate phenotypes should combine to give unprecedented power to determine susceptibility genes for this disease. Our study design is motivated by several considerations. The time is ripe for merging finer phenotypic information with rigorous diagnosis, and the analytic tools are in place, both for finer phenotypic characterization and the joint analysis of phenotypes and genotypes. In terms of mental health, African Americans are an underserved population. The genetic basis of SCZ in the African-American population must have its roots in both Africa and Europe. if the liability alleles for SCZ were different on the two continents, either in kind or frequency, then what we learn from the study of peoples of European ancestry will not necessarily transfer seamlessly to the African population and, by extension, to the African-American population. Therefore it is essential to study SCZ genetics in African-American populations. Finally, we have an outstanding track record of African American participation in research studies, and a deep appreciation of their population genetics.

描述（由申请人提供）：现在很明显，大型样本对于在精神分裂症（SCZ）的遗传学方面取得了很大进展至关重要。为了确定对SCZ负有责任的基因，我们将招募大量和多样化的1260个非裔美国家庭，主要来自美国东南部，所有这些家庭至少有一个被诊断出患有SCZ的成员。这组家庭的很大一部分将有助于标准受影响的兄弟姐妹和相对成对的链接分析，以及对神经认知性状的定量性状基因座（QTL）分析。整个样本将用于在感兴趣的候选区域的混合映射，该项目还通过检查受SCZ及其扩展家庭成员影响的人的认知能力的遗传影响，为QTL分析奠定了基础。如果没有多个参与站点使用相同的协议，就不可能招募这个少数样本。八个机构网站已在合作的ROL下合作，以实现精神障碍的临床研究，以实现这一目标。该协作结合了有关诊断，神经认知评估，家庭招聘和遗传分析的专业知识。大量样品和精制的多元表型应结合起来，以确定对该疾病的易感基因的前所未有的能力。 我们的研究设计是由几个考虑因素激励的。将更精细的表型信息与严格诊断合并的时间已经成熟，并且已经到位，既可以进行更精细的表型表征和表型和基因型的联合分析。在心理健康方面，非裔美国人是服务不足的人群。非裔美国人人口中SCZ的遗传基础必须源于非洲和欧洲。如果SCZ的责任等位基因在两大洲或频率上都不同，那么我们从对欧洲血统的研究中学到的东西不一定会无疑是无缝地转移到非洲人口，并扩展到非裔美国人人口。因此，研究非裔美国人人口中的SCZ遗传学至关重要。最后，我们在非裔美国人参与研究研究以及对其人口遗传学的深刻欣赏方面拥有出色的记录。