Schizophrenia Liability Genes among African Americans

非裔美国人的精神分裂症责任基因

• 批准号: 6942683
• 负责人: Alberto B. SANTOS
• 金额: $ 64.26万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-18 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6942683
• 关键词: Schizophrenia; Liability; Genes; among; African

EXCEED THE SPACE PROVIDED. It is now obvious that large samples are essential to make much headway on the genetics of Schizophrenia. To identify the genes that underlie'the liability of Schizophrenia; we~wiH recruit aMarge sampleof African American families, primarily fromthe southeasternUS, all of whom have at least one person diagnosed with Schizophrenia. A substantial portion of this set of families will contribute to standard Affected Sibling and Relative Pair linkage analysisand to Quantitative Trait Locus (QTL)analysis of neurocognitive traits; the entire sample will be usedfor admixture mapping in candidate regions of interest. This project also lays the foundation for QTL analysis by examininggenetic influences on cognitive abilities among persons affected by Schizophrenia and their extendedfamily members. This minority sample would be impossible to recruit wifh'ouf multiple participating sifes usirig ffie same protocol Eight insfitufioriaf sKes Rave teamed up under' the Collaborative RQls for Clinical Studies of Mental Disorders to accomplish this goal. This collaboration marries expertise in diagnoses, neuTocognrtKre assessments, family recruitment, and genetic analyses. Substantial samples and refined, multivariatephenotypesshould combineto give unprecedented power to determine susceptibility genes for this disease. Our study is motivated by several considerations. The time is ripe for mergingfiner phenotypic information from rigorous diagnosis, and the analytic tools are in place, both for finer phenotypic characterization and the joint analysisof phenotypes end genotypes. In terms of mental health, AfricanAmerican are an underserved population. The genetic basis of Schizophrenia in the African American population must have ft roots in both Africa and Europe. If the liability alleles for Schizophrenia were different in the two continents, either in kind or frequency, then what-we learn from the study of peoples of European anees-trywill not-necessarily transfer semlessly to the African population and, by extension, to the African American population. Therefore it is essential to study the geneticsof Schizophrenia in African Americanpopulations. Finally, we have and outstanding track record of African American participation in researchstudies,and a deep appreciation of their population genetics. PERFORMANCE SITE ========================================Section End===========================================

超过提供的空间。现在很明显，大型样本对于精神分裂症的遗传学取得了很大进展至关重要。确定精神分裂症责任的基因；我们将招募非洲裔美国家庭的Amarge样本，主要来自东南努斯，所有这些家庭至少有一个被诊断出患有精神分裂症的人。这组家族的很大一部分将有助于标准受影响的兄弟姐妹和相对成对的链接分析，以及对神经认知性状的定量性状基因座（QTL）分析；整个样本将用于候选感兴趣地区的混合映射。该项目还通过检查受精神分裂症及其扩展成员影响的人的认知能力的影响来奠定QTL分析的基础。这个少数族裔样本将不可能招募多个参与的sifes usirig ffie同样的协议八个Insfitufioriaf Skes rave rave comply在“协作RQLs”下进行了精神障碍的临床研究，以实现这一目标。这种合作与诊断，中性知识评估，家庭招聘和遗传分析的专业知识结合了。大量样品和精制的多次肾上腺素应该组合具有前所未有的能力来确定该疾病的易感基因。我们的研究是出于几个考虑因素的动机。从严格的诊断中合并表型信息的时间已经成熟，并且分析工具已经到位，既可以进行更精细的表型表征，又是表型结合分析的结合分析。在心理健康方面，非洲人是服务不足的人群。非洲裔美国人口中精神分裂症的遗传基础必须在非洲和欧洲均具有英尺的根源。如果在两大洲（无论是种类还是频率）中的精神分裂症责任等位基因不同，那么我们从对欧洲贫民窟人民的研究中学到的东西 - 不必要地无需在非洲人口中毫不犹豫地转移到非洲人口，并扩展到非洲裔美国人口。因此，研究非裔美国人人群中精神分裂症的遗传学至关重要。最后，我们拥有非裔美国人参与研究人员的杰出记录，并深深地欣赏了他们的人口遗传学。表演站点=============================================================================================