Amygdala in Brain Function:Basic and Clinical Approaches

杏仁核在脑功能中的作用：基本和临床方法

• 批准号: 6416632
• 负责人: PATRICIA SHINNICK-GALLAGHER
• 金额: $ 4万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6416632
• 关键词: amygdala; behavioral /social science research tag; coping; electrophysiology; emotions; meeting /conference /symposium; neuroanatomy; neuropathology; neuropharmacology; neurophysiology; neuropsychology; neuroregulation; publications; social psychology; travel

DESCRIPTION (provided by applicant): The amygdala is a brain area that has recently become one of the hottest topics in neuroscience. Interest in the amygdala is not limited to scientists but also includes the general public and business professionals who are actively seeking more information about the brain machinery governing emotions that control our coping with ongoing everyday life and impact on social signaling. The objective of this meeting is to provide a forum for presenting cutting edge information on the basic characteristics of amygdala function from neuroanatomical, electrophysiological, behavioral, and imaging studies in animals and humans and to integrate that data with the most recent findings in clinical human diseases in which the function of the amygdala is compromised. The desired outcome of the conference is to discuss and perhaps even to reach consensus on the important issues facing the field which impact on our basic understanding of amygdala function. Top experts in the field will meet together for 2.5 days (March 23-26, 2002) at Moody Gardens on Galveston Island, Texas, to discuss the important issues shaping our basic understanding of amygdala function. In plenary presentations and in discussions, critical questions regarding amygdala function at a basic and clinical level will be addressed. Specifically: 1. What is the functional significance of the specific nuclei of the amygdala? Can we use the term "amygdala" to attribute function to these brain areas? Does functional homogeneity between amygdala nuclei exist? Is the "extended" amygdala an anatomical or functional concept? How relevant is this definition for your results? 2. Is the amygdala a critical part of the neuronal circuitry for stimulus-reward associations? 3. Do drugs act at different sites in the amygdala to affect specific behaviors? Sessions will also address such issues as the nuclear structure and nomenclature of the amygdala between different species that is critical for extrapolation of data, for example, from rat/monkey studies to human studies as well as the organization of inhibition and excitation in the amygdala and the breadth of emotions controlled by the amygdala. Other important questions concern whether the amygdala is an integrator or repositor of memories and the role of the amygdala in withdrawal from drugs of abuse. The clinical implications of these functions will be addressed by discussion of symptomatology caused by amygdala damage in Alzheimer's disease and epilepsy and its function in mental illness including anxiety, depression, schizophrenia, and panic disorder. Throughout these discussions, pharmacological information will be presented to provide a foundation for designing drugs for treatment of amygdala pathology. Conference proceedings will be published as a volume of the Annals of the New York Academy of Sciences.

描述（由申请人提供）：杏仁核是一个大脑区域，具有 最近成为神经科学领域最热门的话题之一。兴趣 杏仁核不仅限于科学家，还包括普通大众和 正在积极寻求更多有关该领域信息的商业专业人士 控制情绪的大脑机制控制着我们应对持续发生的事情 日常生活和对社交信号的影响。这次会议的目的是 提供一个展示有关基本知识的前沿信息的论坛 杏仁核功能的神经解剖学特征， 动物和人类的电生理学、行为学和成像研究 将这些数据与临床人类疾病的最新发现相结合 杏仁核的功能受到损害。期望的结果 这次会议的目的是讨论，甚至可能就以下问题达成共识： 该领域面临的重要问题影响了我们对该领域的基本理解 杏仁核功能。领域顶尖专家齐聚2.5天 （2002 年 3 月 23 日至 26 日）在德克萨斯州加尔维斯顿岛的穆迪花园，讨论 塑造我们对杏仁核功能的基本理解的重要问题。在 全体会议演讲和讨论中，有关杏仁核的关键问题 将讨论基础和临床水平的功能。具体来说： 1. 什么 杏仁核特定核团的功能意义是什么？我们可以吗 使用术语“杏仁核”来将功能归因于这些大脑区域？做 杏仁核之间存在功能同质性吗？是“延长” 杏仁核是一个解剖学或功能概念吗？这个定义的相关性如何 为了你的结果？ 2. 杏仁核是神经元回路的关键部分吗 刺激-奖励关联？ 3. 药物作用的部位是否不同？ 杏仁核影响特定行为？会议也将讨论此类问题 作为不同之间杏仁核的核结构和命名法 对于数据外推至关重要的物种，例如 大鼠/猴子研究到人类研究以及抑制的组织 杏仁核的兴奋度以及由大脑控制的情绪的广度 杏仁核。其他重要问题涉及杏仁核是否是一个 记忆的整合者或储存者以及杏仁核在戒断中的作用 来自滥用药物。这些功能的临床意义将是 通过讨论杏仁核损伤引起的症状来解决 阿尔茨海默病和癫痫及其在精神疾病中的作用，包括 焦虑、抑郁、精神分裂症和恐慌症。纵观这些 讨论，将提出药理学信息，以提供 设计用于治疗杏仁核病理学的药物的基础。会议 会议记录将作为《纽约学院年鉴》的一卷出版 科学。