Amygdala in Brain Function:Basic and Clinical Approaches

杏仁核在脑功能中的作用：基本和临床方法

• 批准号: 6416632
• 负责人: PATRICIA SHINNICK-GALLAGHER
• 金额: $ 4万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6416632
• 关键词: amygdala; behavioral /social science research tag; coping; electrophysiology; emotions; meeting /conference /symposium; neuroanatomy; neuropathology; neuropharmacology; neurophysiology; neuropsychology; neuroregulation; publications; social psychology; travel

DESCRIPTION (provided by applicant): The amygdala is a brain area that has recently become one of the hottest topics in neuroscience. Interest in the amygdala is not limited to scientists but also includes the general public and business professionals who are actively seeking more information about the brain machinery governing emotions that control our coping with ongoing everyday life and impact on social signaling. The objective of this meeting is to provide a forum for presenting cutting edge information on the basic characteristics of amygdala function from neuroanatomical, electrophysiological, behavioral, and imaging studies in animals and humans and to integrate that data with the most recent findings in clinical human diseases in which the function of the amygdala is compromised. The desired outcome of the conference is to discuss and perhaps even to reach consensus on the important issues facing the field which impact on our basic understanding of amygdala function. Top experts in the field will meet together for 2.5 days (March 23-26, 2002) at Moody Gardens on Galveston Island, Texas, to discuss the important issues shaping our basic understanding of amygdala function. In plenary presentations and in discussions, critical questions regarding amygdala function at a basic and clinical level will be addressed. Specifically: 1. What is the functional significance of the specific nuclei of the amygdala? Can we use the term "amygdala" to attribute function to these brain areas? Does functional homogeneity between amygdala nuclei exist? Is the "extended" amygdala an anatomical or functional concept? How relevant is this definition for your results? 2. Is the amygdala a critical part of the neuronal circuitry for stimulus-reward associations? 3. Do drugs act at different sites in the amygdala to affect specific behaviors? Sessions will also address such issues as the nuclear structure and nomenclature of the amygdala between different species that is critical for extrapolation of data, for example, from rat/monkey studies to human studies as well as the organization of inhibition and excitation in the amygdala and the breadth of emotions controlled by the amygdala. Other important questions concern whether the amygdala is an integrator or repositor of memories and the role of the amygdala in withdrawal from drugs of abuse. The clinical implications of these functions will be addressed by discussion of symptomatology caused by amygdala damage in Alzheimer's disease and epilepsy and its function in mental illness including anxiety, depression, schizophrenia, and panic disorder. Throughout these discussions, pharmacological information will be presented to provide a foundation for designing drugs for treatment of amygdala pathology. Conference proceedings will be published as a volume of the Annals of the New York Academy of Sciences.

描述（由申请人提供）：杏仁核是一个大脑区域 最近成为神经科学中最热门的话题之一。对 Amygdala不仅限于科学家，还包括公众和 积极寻求更多信息的商业专业人员 脑机制管理情绪，以控制我们的应对 日常生活和对社会信号的影响。这次会议的目的是 提供一个论坛，以介绍基本的尖端信息 来自神经解剖学的杏仁核功能的特征， 动物和人类的电生理，行为和成像研究，以及 将数据与临床人类疾病的最新发现相结合 其中杏仁核的功能受到损害。期望的结果 会议是讨论甚至可以就 该领域面临的重要问题，这影响了我们对我们对的基本理解 杏仁核功能。该领域的顶级专家将共同开会2.5天 （2002年3月23日至26日）在德克萨斯州加尔维斯顿岛的穆迪花园中讨论 塑造我们对杏仁核功能的基本理解的重要问题。在 全体演讲和讨论中，有关杏仁核的关键问题 将解决基本和临床水平的功能。具体：1。什么 杏仁核的特定核的功能意义是吗？我们可以吗？ 使用“杏仁核”一词将功能归因于这些大脑区域？做 存在杏仁核之间的功能均匀性吗？是“扩展” 杏仁核是解剖或功能概念？这个定义有多相关 为了您的结果？杏仁核是神经元电路的关键部分 刺激奖励联想？ 3。在不同地点的不同地点做毒品 杏仁核影响特定行为？会议也将解决此类问题 作为不同的杏仁核的核结构和命名法 对于数据推断至关重要的物种，例如 大鼠/猴子研究人类研究以及抑制组织 和杏仁核中的激发以及情绪的广度 杏仁核。其他重要问题涉及杏仁核是否是 记忆的集成商或存储库以及杏仁核在退出中的作用 来自滥用药物。这些功能的临床意义将是 通过讨论由杏仁核损害引起的症状学 阿尔茨海默氏病和癫痫及其在精神疾病中的功能 焦虑，抑郁，精神分裂症和恐慌症。整个这些 讨论，将提供药理学信息，以提供 设计用于治疗杏仁核病理学的药物的基础。会议 会议记录将作为纽约学院年鉴的卷 科学。