ROCHESTER AREA PEPPER CENTER

罗切斯特地区胡椒中心

• 批准号: 6029770
• 负责人: George N. ABRAHAM
• 金额: $ 62.2万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6029770
• 关键词: aging

The renewal of the Rochester Area Pepper Center (RAPC) builds on the experience of the previous 3 + years. The current RAPC's 2 intervention (IS) and 2 intervention development (IDS) studies focused on evaluating ways to improve or maintain the functional status of the elderly at various stages of physical dependency using standard exercise or pharmacologic interventions and pre- and post-treatment methods of functional assessment. Excellent progress has resulted in 23 publications from the IDs or IDSs, 93 from research of RAPC faculty, and 49 from work funded by the RDC. Despite past progress, the new proposal moves in a new direction. We will integrate basic mechanistic research into 3 clinical IDSs. IDS#1 extends our successful IS of Acute Respiratory Tract Infections (ARTI) in the frail elderly to determine if alterations in immunologic and thrombotic status are predisposers or contributors to, the functional decline noted in ARTI. IDS#2 builds on the current IS findings showing that resistance exercise training does not greatly improve myofibrillar protein synthesis in healthy elderly subjects. The new goal is to determine if a 'more youthful' rate of myofibrillar protein synthesis will result from gonadal steroid therapy thus minimizing the age-related skeletal muscle atrophy. In IDS#3 complementary approaches will be used to study the disease- or age-related declines in neural mechanisms governing spatial orientation and equilibrium control. These approaches include standing balance (postural control), eye-head and eye- head-hand coordination, and visual motion processing that distinguishes self- from externally -initiated movements. The goal is to clarify the parameters that maintain and influence sensory-motor integration between subject and environment. Research Development (RD), Research Resource ; [Biostatistics (RRB)], Demonstration and Information Dissemination (DID), and Administrative (LA) Cores contribute to all RAPC functions. The Cores a) provide seed money for new initiatives and to support the career development of junior faculty (RD); b) provide methods (RRA) for accurate assay of glutathione metabolism for the IDS and other ongoing research; c) assist in the experimental design and statistical analysis of data (RRB); d) inform the medical and lay communities of the RAPC's work and publicize its educational programs (DIDC); and e) provide the leadership, administrative structure and oversight (LA) needed to fulfill the goals of the IDS and Cores. The abiding principle in developing the new RAPC was that its studies and functions, relate and contribute to ongoing clinical and research programs at the U of R Medical Center thereby enhancing the Center's function and significance.

罗切斯特地区胡椒中心 (RAPC) 的更新建立在 过去3年以上的经验。 当前RAPC的2次干预 (IS) 和 2 项干预开发 (IDS) 研究重点评估 改善或维持老年人功能状态的方法 使用标准锻炼或身体依赖的各个阶段 药物干预以及治疗前后的方法 功能评估。 取得了巨大进展，已发表 23 篇出版物 来自 ID 或 IDS，93 个来自 RAPC 教员的研究，49 个来自工作 由 RDC 资助。 尽管过去取得了进展，但新提案提出了新的要求 方向。 我们将把基础机制研究融入3个临床领域 IDS。 IDS#1 扩展了我们成功的急性呼吸道 IS 体弱老年人的感染（ARTI）以确定是否发生改变 免疫和血栓状态是诱发因素或促成因素 ARTI 中注意到功能下降。 IDS#2 建立在当前 IS 调查结果的基础上 表明抗阻运动训练并没有太大改善 健康老年受试者的肌原纤维蛋白合成。 新目标 是为了确定肌原纤维蛋白的“更年轻”率是否 合成将由性腺类固醇治疗产生，从而最大限度地减少 与年龄相关的骨骼肌萎缩。 在 IDS#3 中，互补方法 将用于研究与疾病或年龄相关的神经衰退 控制空间定向和平衡控制的机制。 这些 方法包括站立平衡（姿势控制）、眼头法和眼-头法。 头手协调以及区分的视觉运动处理 来自外部发起的自我运动。 目标是澄清 维持和影响感觉运动整合的参数 主体和环境。 研究开发（RD）、研究资源； [生物统计学（RRB）]、演示和信息传播（DID）、 行政 (LA) 核心负责所有 RAPC 职能。 核心 a) 为新举措提供种子资金并支持职业生涯 初级教师的发展（RD）； b) 提供准确的方法（RRA） IDS 的谷胱甘肽代谢测定和其他正在进行的研究； c) 协助实验设计和数据统计分析（RRB）； d) 向医疗界和非专业界通报 RAPC 的工作并进行宣传 其教育计划（DIDC）； e) 提供领导， 实现以下目标所需的行政结构和监督（LA） IDS 和核心。 开发新 RAPC 的一贯原则是 它的研究和功能与正在进行的临床相关并有助于 和研究项目，从而增强了R大学医学中心的 中心的作用和意义。