MOLECULAR RESOURCES FACILITY ENHANCEMENT

分子资源设施增强

• 批准号: 3521283
• 负责人: George N. ABRAHAM
• 金额: $ 13.7万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-10 至 1993-05-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3521283
• 关键词: HIV infections; bacterial genetics; biomedical equipment resource; biomedical facility; fungal genetics; molecular biology; molecular genetics; nucleic acid structure; protein engineering; protein structure; protein structure function; virus genetics

This proposal requests funds for the acquisition of instruments to augment the MOLECULAR RESOURCES CORE FACILITY at the University of Rochester. Specifically, gradient HPLC systems, oligonucleotide synthesizers, and preparative ultracentrifuges are required to enhance our present and highly used protein purification and nucleic acid core laboratories. This request is supported by a primary user group of THIRTY-ONE investigators and additionally new faculty who comprise a secondary user group. Appropriate institutional support has been committed for technical assistance, construction of new core laboratory facilities, and purchase of required supporting equipment. The facility is centrally located in the medical center and easily accessed by faculty and personnel in all of the Medical School departments, and is also used as the core facility for researchers in the dept. of Biology. The MOLECULAR RESOURCES CORE i.s staffed by trained technical personnel, and each component is under the guidance of a faculty member who is an expert in the area. A facility advisory committee headed by Dr. Abraham, and comprised of Dr. Barbara Iglewski (chair of Microbiology), Dr. Martin Gorovsky (chair of Biology) and Dr. Fred Sherman (chair of Biochemistry), monitors the use and functioning of the facility. The Molecular Resources Core has served its intended function of forming an active center for researchers in the medical center and University departments and has thus far admirably fulfilled its intended function.

该提案请求资金用于购买工具 增强大学的分子资源核心设施 罗切斯特。 具体而言，梯度 HPLC 系统、寡核苷酸 需要合成器和制备型超速离心机来增强 我们目前广泛使用的蛋白质纯化和核酸核心 实验室。 该请求得到主要用户组的支持 三十一名研究人员和另外的新教职人员组成 次要用户组。 适当的机构支持 致力于技术援助、新核心实验室建设 设施，并购买所需的配套设备。 设施 位于医疗中心的中心位置，教职人员可以轻松到达 以及医学院所有部门的人员，也使用 作为该部门研究人员的核心设施。生物学。 这 分子资源核心配备了经过培训的技术人员，并且 每个部分都在专家教职人员的指导下 在该地区。 由亚伯拉罕博士领导的设施咨询委员会，以及 由 Barbara Iglewski 博士（微生物学主席）、Martin 博士组成 Gorovsky（生物学系主任）和 Fred Sherman 博士（生物学系主任） 生物化学），监控设施的使用和功能。 这 分子资源核心已经实现了其形成一个 医学中心和大学研究人员活跃中心 部门，迄今已出色地履行了其预期职能。