COMPREHENSIVE ORAL HEALTH RESEARCH CENTER FOR DISCOVERY

综合口腔健康研究中心的发现

• 批准号: 6379902
• 负责人: TIMOTHY A DEROUEN
• 金额: $ 228.03万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6379902
• 关键词: oral health

We propose to establish a comprehensive Oral Health Research Center of Discovery that has its central theme "The basis of oral and craniofacial health and susceptibility to disease: a focus on the child as a key to lifelong oral health." Thus, this Center is designed to address the oral/craniofacial health of children, an approach that has great potential to produce life-long oral health, in a population recently cited by Congress as a priority for NIH. Seven specific aims are delineated which progress from basic research to provide new insight into origins of disease susceptibility in children; to translation of basic knowledge into new diagnostics, tretments, and preventive interventions; to evaluation of the efficacy and effectiveness of the new interventions when applied to populations; to outreach designed to communicate the findings and educate professionals to conduct more research. The Center proposal consists of five cores (administrative, outreach, biometry, basic science, and clinical) and fourteen ongoing funded projects. are affiliated with the Center, which leverages the NIDR investment of $7.96 million direct costs into a Center with budgets exceeding $30.9 million. The projects are organized into four clusters around the topics of innate host defense and mucosal health, periodontal disease, craniofacial disorders, and cries, with cluster coordinators who will organize meetings and ensure communication and collaboration. Quarterly Center-wide meetings with scientific presentations by investigators will encourage inter-cluster collaboration. The Center involves three health science schools (Medicine, Dentistry, and Public Health); Children's hospital and Regional Medical Center, insurance carrier Washington Dental Services; Departments of Health of Washington and Micronesia; and collaboration with four foreign universities. The Center capitalizes on established strengths and activities in basic biological, clinical, behavioral and health services research and brings them to bear on understanding and addressing susceptibility to oral and craniofacial diseases and disorders in children. Highlights include new investigations into basic cellular responses to oral bacterial biofilms, expanding community demonstration research to increase access to preventive dental care for children, enhancing an established unique short-term research training institute for faculty, and follow-up on a Center-sponsored outreach symposium "Children Our Future: Ethics, Health Policy, Medical/DENTAL Care for Children" which has garnered national attention.

我们建议建立一个综合性口腔健康探索研究中心，其中心主题是“口腔和颅面健康的基础与疾病易感性：关注儿童，将其作为终身口腔健康的关键”。因此，该中心旨在解决儿童的口腔/颅面健康问题，这种方法在最近被国会列为 NIH 优先事项的人群中具有实现终生口腔健康的巨大潜力。制定了七个具体目标，这些目标从基础研究进展到为儿童疾病易感性起源提供新的见解；将基础知识转化为新的诊断、治疗和预防干预措施；评估新干预措施应用于人群时的功效和效果；旨在传达研究结果并教育专业人员进行更多研究的外展活动。该中心提案由五个核心（行政、外展、生物测定、基础科学和临床）和十四个正在进行的资助项目组成。隶属于该中心，该中心利用 NIDR 的 796 万美元直接成本投资，建立一个预算超过 3090 万美元的中心。这些项目围绕先天宿主防御和粘膜健康、牙周病、颅面疾病和哭泣等主题分为四个组，组协调员将组织会议并确保沟通和协作。每季度一次的中心范围内的会议以及研究人员的科学演讲将鼓励集群间的合作。该中心涉及三个健康科学学院（医学、牙科和公共卫生）；儿童医院和地区医疗中心、保险公司 Washington Dental Services；华盛顿和密克罗尼西亚卫生部；并与四所国外大学合作。该中心利用基础生物、临床、行为和健康服务研究方面的既定优势和活动，帮助了解和解决儿童口腔和颅面疾病和病症的易感性。重点包括对口腔细菌生物膜的基本细胞反应的新研究、扩大社区示范研究以增加儿童获得预防性牙科护理的机会、加强已建立的独特的教师短期研究培训机构以及对中心资助的外展活动的后续行动“儿童我们的未来：道德、卫生政策、儿童医疗/牙科护理”研讨会引起了全国关注。