INTEGRATED UPGRADE OF THE NMR INSTRUMENTATION FACILITY

核磁共振仪器设施综合升级

• 批准号: 6052307
• 负责人: George L McLendon
• 金额: $ 25.47万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6052307
• 关键词: biomedical equipment purchase; nuclear magnetic resonance spectroscopy

The Department of Chemistry at Princeton University requests funds from the National Center for Research Resources (NCRR) for the purpose of an integrated upgrade of the NMR instrumentation facility, with the focus on biomolecular and bioanalytical applications. The centerpiece for this integrated upgrade is a new 400 MHz NMR spectrometer, which will replace an outdated machine and remove the bottleneck of routine and semi-routine applications. At the same time this enhancement will allow more efficient use of the existing high-field spectrometers for demanding biomolecular research. Additional items of the integrated upgrade will extend the capacity of these high-field instruments. They will open new research opportunities and serve critical research needs primarily in the field of structure, characterization, and dynamics studies of biomolecules. These units are: a complete LC-NMR accessory kit, a slow-spinning high- resolution MAS probehead, a 13C-15N detection optimized triple resonance probehead and a modern computer for efficient off-line data analysis and structure calculations. This upgrade is critical to the success of the research projects in the Department, specifically those of the core user group of eleven faculty members. When implemented, this integrated upgrade of the NMR instrumentation facility will have greatly expanded our total capabilities and increased the efficiency of the highest field NMR spectrometers and associated units, critical for biostructural studies , for a modest total investment.

普林斯顿大学化学系向国家研究资源中心 (NCRR) 请求资金，用于对 NMR 仪器设施进行综合升级，重点关注生物分子和生物分析应用。此次集成升级的核心是新型 400 MHz NMR 波谱仪，它将取代过时的机器并消除常规和半常规应用的瓶颈。同时，这种增强功能将允许更有效地利用现有的高场光谱仪来进行要求苛刻的生物分子研究。集成升级的附加项目将扩展这些高场仪器的能力。他们将开辟新的研究机会，并主要满足生物分子结构、表征和动力学研究领域的关键研究需求。这些装置包括：完整的 LC-NMR 附件套件、慢速旋转的高分辨率 MAS 探头、13C-15N 检测优化的三重共振探头以及用于高效离线数据分析和结构计算的现代计算机。此次升级对于该系研究项目的成功至关重要，特别是由 11 名教职人员组成的核心用户组的研究项目的成功。实施后，核磁共振仪器设施的集成升级将大大扩展我们的总体能力，并提高最高现场核磁共振波谱仪和相关装置的效率，这对生物结构研究至关重要，而且总投资不大。