Gravitational Effects on Living Systems: Mechanosensing

重力对生命系统的影响：机械传感

• 批准号: 6359876
• 负责人: Ruth Anne Eatock
• 金额: $ 2.88万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6359876
• 关键词: gravity; mechanoreceptors; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): The seventh biennial Gordon Research Conference on Gravitational Effects on Living Systems will be held July 1-6, 2001 at Connecticut College. The theme of the meeting is mechanosensing, an ancient sensory capability. Approximately 100 participants are expected, including 23-25 speakers and 13 discussion leaders. The participation of trainees will be actively sought. While gravity affects living systems in many ways, mechanosensing is an appropriate focus for the meeting. Gravity is detected by mechanosen-sors, but most importantly for the meeting's success, this is an exciting and critical time for research on mechanosensors. The crystal structure of a prokaryotic mechanosensitive channel has recently been elucidated. Behavioral screens of eukaryotic genetic model animals, the yeast, roundworm and fruitfly, have yielded different mechanosensory cascades, including two putative classes of mechanosensory ion channels. Strong functional parallels have recently been shown between the mechanosensory chordotonal organs of flies and the sensory hair cells of the vertebrate inner ear. Intense genetic scrutiny of the mammalian inner ear has produced several pivotal successes in identifying genetic mutations underlying inner ear pathology in mice and humans. In addition to such work on specialized mechanosensors, there have been major recent advances in understanding the responses of nonmechanosensory tissues (muscle, bone, shoots and roots of plants) to mechanical input. The proposed meeting will bring together scientists who don't normally have a chance to meet either because they study different kinds of organisms (microorganisms, plants or animals), or different kinds of mechanical responses (mechanically evoked cascades in specialized mechanosensors vs. tissues that re- model in response to mechanical inputs, including gravity), or because they take widely different approaches (physiology vs. genetics). Moreover, the Gordon Conference format facilitates informal communications and discussions of controversial issues. These factors will promote inter-disciplinary transfer of ideas and approaches and the generation of new strategies for the study of mechanotransduction.

描述（由申请人提供）：第七个双年展戈登研究 关于生活系统重力影响的会议将于7月1-6日举行 2001年在康涅狄格学院。 会议的主题是机械感应，一个 古代感官能力。预计约有100名参与者， 包括23-25位演讲者和13位讨论领导者。 参与 学员将积极寻求。 尽管重力在许多方面都会影响生活系统，但机械感应是 会议的适当重点。 重力是通过机械词检测到的，但是 最重要的是，这是会议的成功，这是一个令人兴奋且至关重要的 时间进行机械传感器的研究。 核的晶体结构 机械敏感的通道最近已被阐明。行为屏幕 真核生物遗传模型动物，酵母，round虫和果蝇，具有 产生了不同的机械感觉级联反应，包括两个推定的类别 机械增强离子通道。最近有强大的功能相似之处 在苍蝇的机械感觉核孔器官和感觉之间显示 脊椎动物内耳的毛细胞。 严格的基因审查 哺乳动物的内耳在识别方面取得了几个关键的成功 小鼠和人类内耳病的基因突变。 在 除了在专用机械传感器上的此类工作外，还有主要 了解非机密感觉组织的响应的最新进展 （植物的肌肉，骨骼，芽和根部）到机械输入。 拟议的会议将聚集在一起，通常没有通常没有的科学家 有机会见面，因为他们研究了不同的生物 （微生物，植物或动物）或不同种类的机械反应 （在专门的机械传感器与组织中机械诱发的级联 响应机械输入（包括重力）的模型，或者因为它们采用 广泛不同的方法（生理学与遗传学）。 而且，戈登 会议格式有助于非正式沟通和讨论 有争议的问题。这些因素将促进跨学科的转移 思想和方法以及研究的新策略 机械转导。