Advanced Research Training in the Biology of the Inner Ear and Related Systems

内耳及相关系统生物学高级研究培训

• 批准号: 10617170
• 负责人: Ruth Anne Eatock
• 金额: $ 3.35万
• 依托单位: MARINE BIOLOGICAL LABORATORY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10617170
• 关键词: Acceleration; Address; Affect; Age; American; Area; Atmosphere; Auditory; Automobile Driving; Biological; Biological Models; Biology; Central Nervous System; Chalk; Clinical; Collaborations; Communication; Communities; Complex; Development; Developmental Cell Biology; Education; Educational Curriculum; Educational process of instructing; Enrollment; Environment; Equilibrium; Faculty; Feedback; Fostering; Foundations; Functional disorder; Genetic; Goals; Health; Hearing; Hearing problem; Human; Institution; Instruction; Investigation; Knowledge; Laboratories; Labyrinth; Learning; Mentors; Methods; Modeling; Molecular; Participant; Pathway interactions; Patients; Population; Postdoctoral Fellow; Problem Solving; Research; Research Personnel; Research Project Grants; Research Training; Science; Scientific Inquiry; Scientist; Sensory; Shoulder; Side; Site; Structure; Students; System; Talents; Technical Expertise; Techniques; Time; Training; Translating; Translations; Underrepresented Populations; Underrepresented Students; Work; career; career development; design; economic impact; education research; equilibration disorder; experience; gene therapy; graduate student; hearing impairment; improved; innovation; instructor; interest; laboratory curriculum; laboratory experience; lateral line; lectures; marine; neural; neural prosthesis; neurophysiology; next generation; peer networks; programs; recruit; response; role model; socioeconomics; stem cell biology; theories; tool; translational progress; undergraduate student

PROJECT ABSTRACT Inner ear dysfunction and the associated problems with hearing and balance affect about 30 million Americans and that number is expected to grow as the population ages. Despite the enormous socioeconomic impact, however, hearing and balance are the most poorly understood of all the senses. One significant reason for this gap in our knowledge is the technical difficulties unique to inner ear research that are a discouraging barrier to new investigators. To address this challenge, we have designed an ambitious three-week course, the Biology of the Inner Ear (BIE) course, to train new investigators in advanced research approaches to the biology of hearing and balance. In each course, 18 students are taught by a team of leading scientists and clinicians. The course will be held in the summers of 2021, 2023 and 2025 at the Marine Biological Laboratory (MBL) in Woods Hole, MA. For the intervening summers of 2022 and 2024, we plan on-site orientation programs for faculty from under-represented groups or who are hearing impaired, with the goals of increasing the diversity of faculty role models at the BIE course and attracting a greater diversity of students. The BIE course was first offered in 2007 and thereafter biennially through 2019. Each course was very well-received by students and faculty, and their feedback provided successive improvements, culminating in the present curriculum. Using the focused approach that typifies other highly successful MBL courses, BIE is designed to meet specific needs of new researchers in auditory and vestibular science. The course will continue to enroll a class comprising graduate students, postdoctoral researchers, clinician-scientists, and established investigators entering the field for the first time. These talented students will be provided with instruction and hands-on laboratory training in cutting-edge, rigorous techniques and specialized methods that are unique to investigations of the inner ear and auditory, vestibular, and lateral line systems. Through lectures, research seminars, roundtable discussions, tutorials, and informal interactions as students and instructors work side-by- side in the laboratory, the BIE course will foster the development of the students as investigators and provide the opportunity to establish long-lasting mentoring relationships. These interactions will emphasize problems, concepts, and theories that are driving current research; innovative approaches; and strategies to translate discoveries into meaningful improvements in human health. BIE is designed to enhance the pipeline of talented, highly motivated scientists entering the field, providing instruction that will challenge them and help them undertake independent and original research, and introducing them to networks within the hearing and balance community that will encourage their career development. This training will advance the pace of scientific discoveries and promote their translation into treatments that improve the lives of those suffering from hearing and balance disorders.

项目摘要 内耳功能障碍以及相关的听力和平衡问题影响着约 3000 万美国人 随着人口老龄化，这一数字预计还会增加。尽管社会经济影响巨大， 然而，听觉和平衡是所有感官中最难理解的。造成这一现象的一个重要原因是 我们的知识差距是内耳研究特有的技术困难，这是一个令人沮丧的障碍 新的调查员。为了应对这一挑战，我们设计了一个雄心勃勃的为期三周的课程：生物学 内耳（BIE）课程，培训新研究人员进行生物学的高级研究方法 听力和平衡能力。每门课程都有 18 名学生由顶尖科学家和临床医生组成的团队授课。 该课程将于 2021 年、2023 年和 2025 年夏季在海洋生物实验室 (MBL) 举行 马萨诸塞州伍兹霍尔。在 2022 年和 2024 年的夏季，我们计划为以下人员举办现场迎新活动： 来自代表性不足群体或听力障碍的教师，其目标是增加教师的多样性 教师在 BIE 课程中树立榜样，并吸引更多元化的学生。 BIE课程是第一个 2007 年开设，此后直至 2019 年每两年开设一次。每门课程都受到学生的好评， 教师们的反馈提供了连续的改进，最终形成了目前的课程。使用 BIE 是其他非常成功的 MBL 课程的典型集中方法，旨在满足特定的需求 听觉和前庭科学新研究人员的需求。课程将继续招生 由研究生、博士后研究人员、临床科学家和知名研究人员组成 第一次进入这个领域。这些才华横溢的学生将获得指导和实践机会 尖端、严格的技术和独特的专业方法的实验室培训 内耳和听觉、前庭和侧线系统的研究。通过讲座、研究 研讨会、圆桌讨论、教程以及学生和教师并肩工作的非正式互动 在实验室方面，BIE 课程将促进学生作为研究人员的发展，并提供 建立长期指导关系的机会。这些互动会强调问题， 推动当前研究的概念和理论；创新方法；和翻译策略 对人类健康有意义的改善的发现。 BIE 旨在增强 有才华、积极性高的科学家进入该领域，为他们提供挑战和帮助的指导 他们进行独立和原创的研究，并将他们介绍给听证会和 平衡社区，鼓励他们的职业发展。此次培训将加快 科学发现并促进其转化为治疗方法，改善患有该疾病的人的生活 听力和平衡障碍。