ALLIANCE FOR CELLULAR SIGNALING - PHASE II

蜂窝信号联盟 - 第二阶段

• 批准号: 6450643
• 负责人: ALFRED G GILMAN
• 金额: $ 100万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6450643
• 关键词: biological signal transduction; biotechnology; cooperative study; high throughput technology; single cell analysis; technology /technique development

We describe plans for establishment of The Alliance for Cellular Signaling - a large-scale (multidisciplinary and multi-institutional) collaborative effort to understand G protein-regulated and related cellular signaling systems, qualitatively and quantitatively. The Alliance will study signaling in two cells from the mouse: the cardiac myocyte and the B lymphocyte. Most of the experimental efforts of the Alliance will be carried out in its own laboratories (rather than those of its Participating Investigators) under the direction of two System Committees. These laboratories will conduct research on a scale that is larger than practical in individual laboratories and/or that is too specialized for most individuals. However, the experimental plan of the Alliance is designed to foster and catalyze conventionally funded research in laboratories throughout the entire signaling research community and thereby to leverage these efforts for the overall goals of the Alliance. We will also organize a large membership to assemble an informational database, whose core elements will be Molecule Pages that describe the properties and interactions of hundreds of relevant signaling molecules. Bridging Projects will be utilized for development and application of critical technologies. A Steering Committee will oversee all aspects of this effort. The experimental efforts of the Alliance will be directed at (1) identification and localization of all relevant molecules in the cells of interest, (2) documentation of the physical and functional interactions of these molecules with each other, (3) quantification of information flow through the signaling systems, and (4) representation of the entire system as a set of interacting processing modules that can be modeled mathematically. The Alliance has promulgated a Policy on Intellectual Property that has been accepted by all participants. All data from Alliance Laboratories will be placed in the public domain by dissemination on the Internet. Funding for the Alliance will be sought from a consortium of major pharmaceutical companies, in addition to this response to RFA GM-99- 007.

我们描述了建立蜂窝信号联盟的计划 - 一种大规模（多学科和多机构的）协作努力，以在定性和定量上理解G蛋白调节和相关的细胞信号系统。联盟将研究小鼠两个细胞中的信号：心肌细胞和B淋巴细胞。联盟的大多数实验工作将在两个系统委员会的指导下在其自己的实验室（而不是其参与研究人员的实验室）中进行。这些实验室将以单个实验室的规模进行研究，并且/或对于大多数人来说太专注。 但是，该联盟的实验计划旨在促进和催化整个信号研究社区的实验室的常规资助研究，从而将这些努力用于联盟的整体目标。我们还将组织一个大型成员资格来组装信息数据库，其核心要素将是描述数百个相关信号分子的特性和相互作用的分子页面。桥接项目将用于开发和应用关键技术。指导委员会将监督这项工作的各个方面。联盟的实验努力将针对（1）在感兴趣的单元中识别和定位所有相关分子，（2）记录这些分子之间的物理和功能相互作用的文献，（（3）信息流通过信号系统的信息流量量化，（4）（4）整个系统表示相互作用的处理模块的代表，可以模型数学。该联盟已颁布了有关所有参与者接受的知识产权政策。联盟实验室的所有数据都将通过互联网传播放置在公共领域。除了对RFA GM-99- 007的回应之外，还将寻求该联盟的资金。