Characterization and modelling of interactions between complex molecules and lipid bilayer.

复杂分子和脂质双层之间相互作用的表征和建模。

• 批准号: 1785754
• 金额: --
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1785754
• 关键词: Characterization; modelling; interactions; between; complex

This project will investigate the way in which complex molecules interact with lipid membranes. The project will involve the characterization of lipid vesicles with varying compositions to mimic different cell types. The interaction of various complex molecules with lipid vesicles will be explored using a range of biophysical techniques including dynamic light scattering, circular and linear dichroism and partitioning experiments. The complex molecules, the lipid bilayers and the interaction of the two, will also be studied using a range of computational tools from molecular dynamics up through various coarse grained techniques. The overall aim is to experimentally determine the properties of these systems and then validate the modelling against the experimental results leading to improved modelling in the future.

该项目将研究复杂分子与脂质膜相互作用的方式。该项目将涉及具有不同组合物与模拟不同细胞类型的脂质囊泡的表征。各种复合物分子与脂质囊泡的相互作用将使用一系列生物物理技术进行探索，包括动态光散射，圆形和线性二科和分配实验。复杂的分子，脂质双层和两者的相互作用也将使用来自各种粗砂技术的分子动力学的一系列计算工具进行研究。总体目的是实验确定这些系统的特性，然后根据实验结果验证建模，从而改善了建模。