HIV risk behaviors in preparation of injectable drugs

注射药物制备过程中的艾滋病毒危险行为

• 批准号: 6492819
• 负责人: Hector M Colon
• 金额: $ 21.15万
• 依托单位: UNIVERSIDAD CENTRAL DEL CARIBE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6492819
• 关键词: HIV infections; behavioral /social science research tag; clinical research; disease /disorder proneness /risk; high risk behavior /lifestyle; human subject; intravenous drug abuse; needle sharing; substance abuse related behavior

The process of acquiring, preparing and dividing up injectable drugs entails an array of behaviors that expose injection drug users (IDUs) to HIV and other blood-borne pathogen. The behaviors include the common use of drug preparation materials and the use of a single syringe to mix, divide and distribute jointly purchased drugs. These risk behaviors can take place even when IDUs are not injecting with the same syringe (i.e., needle sharing). There is compelling evidence that drug preparation (DP) risk behaviors are associated with HIV and hepatitis C virus (HCV) transmission. However, not much is known about the determinants of DP behaviors and very few intervention strategies have been designed to explicitly help IDUs reduce this risky practices. We propose to conduct formative research to identify the determinants of DP risk behaviors among IDUs in Puerto Rico. The goal of the proposed project is to generate the knowledge-base with which to develop an R01 proposal to test the efficacy of a preventive intervention aimed at reducing DP risk behaviors. The proposed formative research has been designed to be implemented in three phases. In a Qualitative Phase we will conduct participant observations, focus groups, and semi-structured interviews to describe in detail the DP behaviors practiced by IDUs in Puerto Rico, and the circumstances under which these behaviors are practiced. In the second phase we will use the findings of the Qualitative Phase, combined with theoretical constructs from several major behavioral theories to develop measures of the DP behaviors and of the factors that can potentially account for these behaviors. In this Measurement Development Phase, we will develop and pilot test a structured interview protocol to measure DP behaviors, as well as the candidate explanatory factors. Finally, we will conduct a prospective study. In this study we will administer the interview protocol to a sample of 400 IDUs. Two weeks after baseline assessment, participants will be interviewed again. The analytical plan will assess the ability of the developed variables to account for DP risk behaviors and will help to identify the prediction of these practices.

获取、准备和分配注射药物的过程涉及一系列使注射吸毒者 (IDU) 接触艾滋病毒和其他血源性病原体的行为。包括共用药品制剂材料、使用同一注射器混合、分割、分配共同购买的药品等行为。即使注射吸毒者没有使用同一注射器注射（即共用针头），这些危险行为也可能发生。有令人信服的证据表明，药物制剂 (DP) 风险行为与 HIV 和丙型肝炎病毒 (HCV) 传播相关。然而，人们对 DP 行为的决定因素知之甚少，也很少有干预策略被设计来明确帮助注射吸毒者减少这种危险行为。我们建议进行形成性研究，以确定波多黎各注射吸毒者中 DP 风险行为的决定因素。拟议项目的目标是生成知识库，用于制定 R01 提案，以测试旨在减少 DP 风险行为的预防性干预措施的有效性。拟议的形成性研究被设计为分三个阶段实施。在定性阶段，我们将进行参与者观察、焦点小组和半结构化访谈，以详细描述波多黎各注射吸毒者实施的 DP 行为以及实施这些行为的环境。在第二阶段，我们将使用定性阶段的发现，结合几种主要行为理论的理论构建，来制定 DP 行为以及可能解释这些行为的因素的衡量标准。在此衡量开发阶段，我们将开发并试点测试结构化面试协议，以衡量 DP 行为以及候选人的解释因素。最后，我们将进行前瞻性研究。在这项研究中，我们将对 400 名注射毒品使用者进行访谈。基线评估两周后，参与者将再次接受采访。分析计划将评估开发变量解释 DP 风险行为的能力，并有助于确定这些做法的预测。