Introducing New drug Preparation Materials to Reduce HIV/HCV Transmission Among

引入新的药物制备材料以减少艾滋病毒/丙型肝炎病毒在人群中的传播

基本信息

批准号：
7140571
负责人：
Hector M Colon
金额：
$ 21.18万
依托单位：
UNIVERSIDAD CENTRAL DEL CARIBE
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-08-15 至 2008-07-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): A growing body of evidence suggests that the shared use of drug preparation materials has an important role in the transmission of HIV and HCV among IDUs. Systematic observations of drug preparation episodes suggest that the main source of contamination of non-syringe materials stems from the common practice of using an injection syringe to pull up water and expel it into a cooker, and to draw up the drug solution from the cooker and distribute it to other syringes. In our preliminary research we have identified the practices by which injection syringes make contact with the other preparation materials and the types of water dispensers and preparation syringes that have the potential to enable IDUs to avoid using injection syringes to prepare and distribute drug solutions. We propose to work with IDUs and community outreach workers in San Juan, Puerto Rico, to develop new practices and to identify new preparation materials that can effectively promote the separation of injection syringes from the process of preparing drug solutions. Research activities will be implemented in three phases: First, we will organize a team comprised of IDUs and community outreach workers who will bench-test candidate materials to identify and select the materials most suitable to permit the separation of the injection syringes from the process of preparing drug solutions. In the second phase, we will develop instructional and promotional materials with which to communicate the risks of using injection syringes in the preparation of drug solutions, and demonstrate to IDUs how the new water dispensers and preparation syringes can be used to keep the injection syringe from making contact with the preparation materials. Finally, we propose to conduct a small-scale field trial in three neighborhoods among approximately 75 IDUs to examine the extent to which the use of syringes in the preparation of drug solutions is reduced and the new materials are adopted, and to assess the safety, performance, and costs of the new materials. The findings and results from the proposed exploratory research will provide the needed knowledge and strategies with which to design a preventive intervention to introduce new drug preparation practices to reduce HIV and HCV transmission among IDUs. Upon termination of the proposed exploratory research, an R01 proposal will be designed to implement a field trial and test the diffusion, sustainability, and efficacy of the new drug preparation practices.

描述（由申请人提供）：越来越多的证据表明，共用药物制剂材料在注射吸毒者之间传播艾滋病毒和丙型肝炎病毒方面发挥着重要作用。对药物制剂事件的系统观察表明，非注射器材料污染的主要来源源于使用注射器将水抽入蒸煮器中，并从蒸煮器中吸取药液并进行处理的常见做法。将其分配给其他注射器。在我们的初步研究中，我们已经确定了注射器与其他制剂材料接触的做法以及有可能使注射吸毒者避免使用注射器来制备和分配药物溶液的饮水机和制剂注射器的类型。我们建议与波多黎各圣胡安的注射吸毒者和社区外展工作人员合作，开发新做法并确定新的制备材料，以有效促进注射器与药物溶液制备过程的分离。研究活动将分三个阶段进行：首先，我们将组织一个由注射吸毒者和社区外展人员组成的团队，对候选材料进行台架测试，以确定和选择最适合将注射器从注射过程中分离出来的材料。制备药物溶液。在第二阶段，我们将制作指导和宣传材料，传达使用注射器配制药物溶液的风险，并向注射吸毒者演示如何使用新型饮水机和配制注射器来防止注射器受到伤害。与制备材料接触。最后，我们建议在三个社区约75名注射吸毒者中进行小规模现场试验，以考察在配制药物溶液时减少使用注射器和采用新材料的程度，并评估其安全性，新材料的性能和成本。拟议的探索性研究的发现和结果将提供所需的知识和策略，用于设计预防性干预措施，引入新的药物制备实践，以减少注射吸毒者中艾滋病毒和丙型肝炎病毒的传播。拟议的探索性研究终止后，将设计 R01 提案来实施现场试验并测试新药物制备实践的扩散、可持续性和功效。

项目成果

期刊论文数量（1）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Pilot trial of an intervention aimed at modifying drug preparation practices among injection drug users in Puerto Rico.

旨在改变波多黎各注射吸毒者药物制备做法的干预试点试验。

DOI：
10.1007/s10461-009-9540-3
发表时间：
2009
期刊：
AIDS and behavior
影响因子：
4.4
作者：
Colon,HectorM;Finlinson,HenrietteA;Negron,Juan;Sosa,Irmaly;Rios-Olivares,Eddy;Robles,RafaelaR
通讯作者：
Robles,RafaelaR