A PILOT STUDY OF NEUROCYSTICERCOSIS TREATMENT

神经囊虫病治疗的试点研究

• 批准号: 6394271
• 负责人: Willard ALLEN HAUSER
• 金额: $ 47.35万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-07 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6394271
• 关键词: clinical research; clinical trials; emerging infectious disease; epilepsy; human subject; human therapy evaluation; nervous system disorder; nervous system disorder therapy

Neurocysticercosis (NC) is endemic in much of the developing world. It is a major cause of neurologic morbidity and is said to be the primary cause of epilepsy. Traditionally considered an exotic disease in the United States, NC is being seen with increasing frequency in the United States. This is related to immigration as well as travel to endemic area. NC accounts for 2 percent of neurologic and neurosurgical admissions in southern California and there are more than 1,000 cases per year in the United States. An outbreak of cysticercosis among orthodox Jews living in New York City was reported after food was contaminated with T. solium eggs by immigrant cooks infected with the pork tapeworm. The Center for Disease Control considers NC an emerging infection, and they are developing programs to track and hopefully eradicate the condition. While a considerable literature exists regarding treatment of NC, for most clinicians, decisions regarding treatment strategies present a serious dilemma. There are few randomized trials of the treatment of NC. These report conflicting results and raise serious questions regarding the efficacy of current treatments and the long-term cost-benefit ratio. None have adequate power to answer even basic questions regarding optimal management. We herein propose a pilot study to develop methods to conduct a multicenter trial to determine of optimal treatment of acute NC.

神经囊尾蚴病 (NC) 在许多发展中国家流行。 它是神经系统发病的主要原因，据说是癫痫的主要原因。 在美国传统上被认为是一种外来疾病，但 NC 在美国的发病率越来越高。 这与移民以及前往流行地区的旅行有关。 NC 占南加州神经科和神经外科住院人数的 2%，美国每年有 1,000 多例病例。 据报道，感染猪肉绦虫的移民厨师在食物中污染了猪带绦虫卵后，居住在纽约市的正统犹太人中爆发了囊尾蚴病。 疾病控制中心认为 NC 是一种新出现的感染，他们正在制定计划来追踪并希望根除这种疾病。虽然有大量关于 NC 治疗的文献，但对于大多数临床医生来说，治疗策略的决策面临着严重的困境。 NC 治疗的随机试验很少。 这些报告的结果相互矛盾，并对当前治疗的疗效和长期成本效益比提出了严重质疑。没有人有足够的能力来回答有关最佳管理的基本问题。 我们在此提出一项试点研究，以开发进行多中心试验的方法，以确定急性 NC 的最佳治疗方法。