EPILEPSY EPIDEMIOLOGY--INCIDENCE & ANTECEDENTS IN ICELAN

癫痫流行病学——发病率

• 批准号: 2037770
• 负责人: Willard ALLEN HAUSER
• 金额: $ 42.77万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-03-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2037770
• 关键词: Europe; age difference; brain disorder diagnosis; case history; computed axial tomography; convulsions; data collection methodology /evaluation; disease /disorder proneness /risk; electroencephalography; epilepsy; human morbidity; human subject; interview; longitudinal human study; medical records; nervous system disorder epidemiology; socioeconomics; statistics /biometry

Seizure disorders are among the most frequently occurring neurologic disorders. Few studies provide comprehensive information on the incidence of the seizures by age, gender, seizure type or epilepsy syndrome, and none incorporate current EEG, CT, and MRI techniques into the diagnostic algorithm. An incidence study of all seizure disorders will be conducted in the island country of Iceland. This country has provided excellent medical care to its citizens at little or no cost for many years, and has an excellent medical record system as well as state of the art equipment for diagnosis and treatment. A comprehensive surveillance network will be established to identify all residents with newly diagnosed seizure disorders over a 4 year period. These cases will provide a comprehensive picture of the occurrence of seizure disorders in the population. Availability of current neurodiagnostic studies on most cases will provide accurate, reliable, and credible population data detailing the descriptive epidemiology of epilepsy. These data will satisfy criticisms of epidemiologic studies of epilepsy leveled by epileptologists and other clinicians. The classical conditions clinically identified as causes of epilepsy (brain trauma, cerebrovascular disease, infection of the central nervous system, tumor, neurologic abnormality from birth manifest by mental retardation or cerebral palsy) can be identified in only about 1/3 of all new cases of epilepsy. Few studies have been conducted on newly diagnosed cases of epilepsy to quantitate risk associated with these factors or to identify other factors which increase the risk for epilepsy. To identify potential risk factors for epilepsy these well characterized incidence cases will be matched to a control group selected from the general population. The study will provide further understanding of the mechanisms associated with established risk factors, allow examination of the role of putative risk factors (e.g., hypertension, depressive illness, alcohol use), and allow exploration of other potential risk factors. Results will lead to new concepts of epileptogensis in humans and to generally applicable interventions, resulting in a reduced frequency of epilepsy and associated neurologic co-morbidity.

癫痫症是最常见的神经系统疾病之一 失调。 很少有研究提供有关发病率的全面信息 按年龄、性别、癫痫类型或癫痫综合征划分的癫痫发作情况，以及 没有一个将当前的脑电图、CT 和 MRI 技术纳入诊断中 算法。 将进行所有癫痫症的发病率研究 在岛国冰岛。 这个国家提供了优秀的 多年来为公民提供很少或免费的医疗服务，并已 优秀的病历系统以及最先进的设备 用于诊断和治疗。 全面的监控网络将 旨在识别所有新诊断癫痫发作的居民 超过 4 年的疾病。 这些案例将提供全面的 人群中癫痫症发生情况的图片。 当前对大多数病例的神经诊断研究的可用性将提供 准确、可靠、可信的人口数据，详细描述了 癫痫流行病学。 这些数据将满足人们的批评 癫痫学家和其他人对癫痫的流行病学研究 临床医生。 临床上确定为癫痫病因的经典病症 （脑外伤、脑血管疾病、中枢神经感染 系统、肿瘤、出生后神经系统异常，表现为精神异常 发育迟缓或脑瘫）仅能在大约 1/3 的人中被识别出来 新的癫痫病例。 对新诊断的研究很少 癫痫病例以量化与这些因素相关的风险或 确定增加癫痫风险的其他因素。 识别 癫痫的潜在危险因素这些明确的发病率 病例将与从一般情况中选择的对照组相匹配 人口。 该研究将有助于进一步了解 与既定风险因素相关的机制，允许检查 假定的危险因素（例如高血压、抑郁症、 饮酒），并允许探索其他潜在的风险因素。 结果将带来人类癫痫发生的新概念，并 普遍适用的干预措施，从而减少了 癫痫和相关的神经系统并发症。