EPILEPSY EPIDEMIOLOGY--INCIDENCE & ANTECEDENTS IN ICELAN

癫痫流行病学——发病率

• 批准号: 2037770
• 负责人: Willard ALLEN HAUSER
• 金额: $ 42.77万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-03-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2037770
• 关键词: Europe; age difference; brain disorder diagnosis; case history; computed axial tomography; convulsions; data collection methodology /evaluation; disease /disorder proneness /risk; electroencephalography; epilepsy; human morbidity; human subject; interview; longitudinal human study; medical records; nervous system disorder epidemiology; socioeconomics; statistics /biometry

Seizure disorders are among the most frequently occurring neurologic disorders. Few studies provide comprehensive information on the incidence of the seizures by age, gender, seizure type or epilepsy syndrome, and none incorporate current EEG, CT, and MRI techniques into the diagnostic algorithm. An incidence study of all seizure disorders will be conducted in the island country of Iceland. This country has provided excellent medical care to its citizens at little or no cost for many years, and has an excellent medical record system as well as state of the art equipment for diagnosis and treatment. A comprehensive surveillance network will be established to identify all residents with newly diagnosed seizure disorders over a 4 year period. These cases will provide a comprehensive picture of the occurrence of seizure disorders in the population. Availability of current neurodiagnostic studies on most cases will provide accurate, reliable, and credible population data detailing the descriptive epidemiology of epilepsy. These data will satisfy criticisms of epidemiologic studies of epilepsy leveled by epileptologists and other clinicians. The classical conditions clinically identified as causes of epilepsy (brain trauma, cerebrovascular disease, infection of the central nervous system, tumor, neurologic abnormality from birth manifest by mental retardation or cerebral palsy) can be identified in only about 1/3 of all new cases of epilepsy. Few studies have been conducted on newly diagnosed cases of epilepsy to quantitate risk associated with these factors or to identify other factors which increase the risk for epilepsy. To identify potential risk factors for epilepsy these well characterized incidence cases will be matched to a control group selected from the general population. The study will provide further understanding of the mechanisms associated with established risk factors, allow examination of the role of putative risk factors (e.g., hypertension, depressive illness, alcohol use), and allow exploration of other potential risk factors. Results will lead to new concepts of epileptogensis in humans and to generally applicable interventions, resulting in a reduced frequency of epilepsy and associated neurologic co-morbidity.

癫痫发作是最常见的神经系统 疾病。 很少有研究提供有关发病率的全面信息 按年龄，性别，癫痫类型或癫痫综合征癫痫发作的癫痫发作，以及 没有一个将当前的脑电图，CT和MRI技术纳入诊断 算法。 将对所有癫痫发作疾病进行一项发病率研究 在冰岛岛国。 这个国家提供了极好的 多年以来，对其公民的医疗保健几乎没有成本，并且 出色的病历系统以及最先进的设备 用于诊断和治疗。 全面的监视网络将是 建立以识别所有已诊断出癫痫发作的所有居民 在4年内的疾病。 这些案例将提供全面的 人口中癫痫发作障碍的情况。 在大多数情况下，当前神经诊断研究的可用性将提供 准确，可靠且可信的人群数据详细说明了描述性 癫痫的流行病学。 这些数据将满足对 癫痫学家和其他癫痫病的流行病学研究 临床医生。 经典条件在临床上被识别为癫痫的原因 （脑外伤，脑血管疾病，中枢神经感染 系统，肿瘤，神经系统异常，来自出生的精神表现 智障或脑瘫）只能在所有大约1/3中识别 癫痫的新病例。 很少对新诊断的研究进行 癫痫病例，以量化与这些因素相关的风险或 确定增加癫痫风险的其他因素。 识别 癫痫的潜在危险因素这些特征性的发生率 案例将与从一般选择的对照组匹配 人口。 该研究将进一步了解 与已建立的风险因素相关的机制，允许检查 推定的危险因素的作用（例如，高血压，抑郁疾病， 饮酒），并允许探索其他潜在的危险因素。 结果将导致人类中癫痫的新概念和 通常适用的干预措施，导致频率降低 癫痫和相关的神经系统合并症。