The neurophysiology of shape and spatial working memory

形状和空间工作记忆的神经生理学

• 批准号: 6321857
• 负责人: ANNE B SERENO
• 金额: $ 26.16万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6321857
• 关键词: Macaca mulatta; behavior test; behavioral /social science research tag; computer data analysis; electrodes; form /pattern perception; histology; neurophysiology; prefrontal lobe /cortex; short term memory; single cell analysis; space perception; temporal lobe /cortex

DESCRIPTION(adapted from applicant's abstract): This proposal examines two kinds of working memory-memory for shape and space- at the cellular level using a single unit recording technique in awake behaving rhesus monkeys. Much work suggests that perceptual processing proceeds along two cortical paths in temporal and parietal cortices, often characterized as the 'what' and where pathways, respectively. Both pathways project to regions of prefrontal cortex. Previous work has not been careful in the manipulation of featural and spatial working memory requirements and no study has compared cell response to both kinds of working memory within the same cortical area with identical visual conditions. Using the proposed paradigms, we have just finished recording from posterior parietal and inferior temporal cortices of animals performing these tasks where we found quite different patterns of findings. This study will provide valuable information as to whether working memory of shape and space are physiologically segregated in prefrontal cortex. We will also be able to report exactly how these types of working memory modulate cell response and how this relates to the sensory and motor response of the cell. Further, we will be able to compare the findings directly to data we have obtained from posterior parietal and inferior temporal cortices. Prefrontal cortex has been implicated in a variety of human neurological and mental diseases, including Parkinson's disease. Huntington's chorea, Korsakoff's disease, and schizophrenia. Little work in the neuropsvchology of memory has focused on short-term or working memory. Characterization of mechanisms related to working memory in prefrontal cortex may prove useful for better understanding what role short-term or working memory deficits play in the cognitive and psychiatric abnormalities that are associated with these conditions.

描述（改编自申请人的摘要）：该提案检查了两个 用于形状和空间的工作记忆内存 - 在蜂窝级别使用 在醒着的恒河猴中，单个单元记录技术。很多工作 表明感知处理沿着两条皮质路径进行 颞叶和顶叶皮质，通常被描述为“什么”和何处 途径分别。这两种途径都向前额叶皮层区域项目。 以前的工作在操纵特征和空间时并不小心 工作记忆要求和没有研究将两个细胞的反应比较 与视觉相同的同一皮质区域内的工作记忆类型 状况。使用拟议的范例，我们刚刚完成录制 动物执行这些动物的后顶叶和下颞皮层 我们发现发现完全不同的任务。这项研究会 提供有关形状和空间是否工作的宝贵信息 在生理上是在额叶皮层中隔离的。我们还将能够 确切地报告这些类型的工作记忆如何调节单元格响应以及如何调节 这与细胞的感觉和运动响应有关。此外，我们将 能够将发现直接与我们从后部获得的数据进行比较 顶叶和下颞皮质。前额叶皮层已牵涉 在包括帕金森的各种人类神经和精神疾病中 疾病。亨廷顿的唱片，科萨科夫氏病和精神分裂症。小的 记忆神经vChology的工作重点是短期或工作 记忆。在前额叶中与工作记忆有关的机制的表征 皮质可能对更好地了解短期角色或 工作记忆缺陷在认知和精神病异常中发挥 与这些条件相关的。