Examining the psychosexual impact of human papillomavirus testing in routine cervical screening

检查人乳头瘤病毒检测在常规宫颈筛查中对性心理的影响

基本信息

批准号：
1764915
负责人：
金额：
--
依托单位：
University College London
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1764915
关键词：
Examining psychosexual impact human papillomavirus

项目摘要

The NHS Cervical Screening Programme aims to prevent cancer by detecting and treating abnormalities of the cervix. Cytology is currently used to detect cervical abnormalities with testing for human papillomavirus (HPV) if cytology results show borderline or low-grade abnormal cell changes. HPV is a highly prevalent sexually transmitted infection and nearly all cases of cervical cancer can be attributed to HPV infection. Research suggests that using HPV testing as the primary test in cervical is more sensitive for detecting high grade precancerous disease. The NHS Cervical Screening Programme is now using HPV testing as the primary test in six sites in England with the intention of rolling this out across the whole of England by 2019. Previous research evaluating the impact of HPV testing in cervical screening suggests that an HPV positive result has an adverse psychosocial impact beyond that experienced by those receiving an abnormal cytology result alone (1). In addition to anxiety and concern there may be other psychological consequences of testing positive for HPV which relate to the sexually transmitted nature of the virus. Previous research suggests that women feel stigmatized, concerned about disclosing their result to others and concerned about their sexual relationships following a HPV positive result (2). The psychosexual impact of a HPV positive result has not been explored in the context of primary HPV testing but it is important that it is evaluated to determine the information needs and support required for women and to reduce the psychosexual burden of an HPV positive result, particularly as there will be far greater numbers of women receiving a HPV positive result than at present.This PhD will explore the psychosexual impact of HPV primary testing in routine cervical screening. The first study will involve using data from the Psychological Effects of Abnormal Pap Smears Questionnaire short form (PEAPS-Q-5), a measure of psychosexual functioning, collected as part of the Psychological Impact of Primary Screening for HPV study (PIPS), collected shortly after women receive their screening result. Differences in psychosexual functioning will be assessed between six groups of women with different combinations of HPV and cytology results: those who test negative for HPV, those who are HPV positive with normal cytology, those who are HPV positive with abnormal cytology, those who tested positive for HPV previously and are attending their 12-month follow up appointment who have persistent HPV and those who tested negative at the 12-month follow up appointment, and a control group who have been screened using cytology only. The second study will be a repeat of the first study but will assess psychosexual functioning 6 and 12 months post screening result. The results of the first two studies will inform further qualitative and quantitative research for the remainder of the PhD. 1. Maissi E, Marteau TM, Hankins M, Moss S, Legood R, Gray A. Psychological impact of human papillomavirus testing in women with borderline or mildly dyskaryotic cervical smear test results: cross sectional questionnaire study. BMJ. 2004;328(7451):1293.2. McCaffery K, Waller J, Nazroo J, Wardle J. Social and psychological impact of HPV testing in cervical screening: a qualitative study. Sexually Transmitted Infections. 2006;82(2):169-74.

NHS宫颈筛查计划旨在通过检测和治疗子宫颈的异常来预防癌症。目前，如果细胞学结果显示出边界或低度异常细胞的变化，则使用人乳头瘤病毒（HPV）检测宫颈异常。 HPV是一种高度普遍的性传播感染，几乎所有宫颈癌病例都可以归因于HPV感染。研究表明，使用HPV测试作为宫颈的主要测试对于检测高级癌前疾病的敏感性更高。 NHS宫颈筛查计划现在正在使用HPV测试作为英格兰六个地点的主要测试，目的是在2019年到2019年在整个英格兰的整个整个英格兰。评估HPV测试在颈椎筛查中的影响表明，HPV阳性结果表明，HPV阳性结果具有不良的心理社会影响，从而受到了不受骨折的结果的不利影响（1）。除了焦虑和关注外，测试HPV阳性的其他心理后果与病毒的性传播性质有关。先前的研究表明，妇女感到受污名化，担心她们的结果向他人披露，并关心HPV阳性结果后的性关系（2）。 The psychosexual impact of a HPV positive result has not been explored in the context of primary HPV testing but it is important that it is evaluated to determine the information needs and support required for women and to reduce the psychosexual burden of an HPV positive result, particularly as there will be far greater numbers of women receiving a HPV positive result than at present.This PhD will explore the psychosexual impact of HPV primary testing in routine cervical screening.第一项研究将涉及使用来自异常的PAP涂片问卷调查表（PEAPS-Q-5）的心理影响的数据，这是一种心理性功能的测量，是HPV研究（PIPS）的主要筛查（PIPS）的心理影响的一部分，在妇女获得妇女后不久收集。在六组妇女之间，将评估具有HPV和细胞学组合不同的女性之间的心理性功能差异：对HPV进行阴性测试的人，HPV呈正常细胞学呈阳性的人，HPV呈阳性的患者，具有异常细胞学的HPV呈阳性，那些对HPV进行了积极测试的人，他们对HPV进行了积极的态度，并在12个小时的时间进行了预约HPV的测试，他们已经进行了预约HPV，并有效地进行了预约HPV，并进行了预期的预期。预约，以及仅使用细胞学筛查的对照组。第二项研究将是第一项研究的重复，但将评估筛查后6个月和12个月的心理功能。前两项研究的结果将为其余的博士学位提供进一步的定性和定量研究。 1。MaissiE，Marteau TM，Hankins M，Moss S，Legood R，GrayA。人乳头瘤病毒测试对具有边界或轻度性颈部宫颈宫颈涂片测试的女性的心理影响：跨部分问卷研究。 BMJ。 2004; 328（7451）：1293.2。 McCaffery K，Waller J，Nazroo J，Wardle J. HPV测试在宫颈筛查中的社会和心理影响：一项定性研究。性传播感染。 2006; 82（2）：169-74。