Genomic Analysis of Salmonella typhi Pathogenesis

伤寒沙门氏菌发病机制的基因组分析

• 批准号: 6369178
• 负责人: PHILIP A YOUDERIAN
• 金额: $ 3.5万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-06 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6369178
• 关键词: Salmonella typhi; South America; bacteria infection mechanism; bacterial genetics; cell line; chromosomes; cooperative study; epithelium; genetic screening; genome; technology /technique development

DESCRIPTION (Adapted from the Applicant's Abstract): This is a proposal to support a sabbatical leave for Dr. Philip Youderian in the laboratory of Dr. Guido Mora located at the Pontificia Universidad Catolica in Santiago, Chile. During this sabbatical leave, the P. I. intends to gain expertise in the study of the interaction of Salmonella typhi with epithelial cell lines. Salmonella continues to be a worldwide health problem and, therefore, understanding the mechanisms by which these microorganisms cause disease is of great importance. During the sabbatical leave, the P. I. intends to apply a combination of functional genomics and bacterial genetics techniques to identify genes that are essential for growth under condition that mimic those encounter during water-borne transmission as well as genes required for growth within epithelial cells.

描述（根据申请人的摘要改编）：这是 在博士的实验室中，为菲利普·尤德里安博士的休假休假。 吉多·莫拉（Guido Mora）位于智利圣地亚哥的Pontificia catolica大学。 在休假期间，P。I。打算在研究中获得专业知识 沙门氏菌伤与上皮细胞系的相互作用。沙门氏菌 继续是全球健康问题，因此，了解 这些微生物引起疾病的机制非常重要。 在休假期间，P。I。打算将 功能性基因组学和细菌遗传学技术来鉴定基因 对于在模仿那些在 水传播的传播以及上皮内生长所需的基因 细胞。