ADOLESCENT MEDICINE TRIAL NETWORK FOR HIV/AIDS

艾滋病毒/艾滋病青少年药物试验网络

• 批准号: 6331146
• 负责人: STEPHEN A SPECTOR
• 金额: $ 21.54万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-16 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6331146
• 关键词: AIDS; AIDS /HIV diagnosis; AIDS /HIV test; AIDS education /prevention; AIDS therapy; HIV infections; adolescence (12-20); behavior therapy; clinical trials; cooperative study; diet therapy; disease /disorder proneness /risk; health behavior; health care referral /consultation; human subject; human therapy evaluation; medical outreach /case finding; patient oriented research; pediatric AIDS; social service; substance abuse related disorder; urban area; young adult human (21-34)

DESCRIPTION (provided by applicant): HIV infection of adolescents remains a significant problem in the U.S. and other industrialized nations. Worldwide, half of all newly infected persons are between the ages of 15 and 24 years. Despite considerable progress in decreasing perinatal transmission of HIV, there has been little impact on the number of newly infected adolescents in the U.S. and the number of youth infected is to a large extent unknown. Identification of HIV infected adolescents is of particular importance and an even greater challenge in San Diego, a city that borders on Mexico and has the most frequently crossed international border in the world. The UCSD Mother-Child- Adolescent HIV Program has made considerable progress in the development of a comprehensive infrastructure for the identification, care and research participation of HIV infected pregnant women, children and adolescents. The goal of this application is to expand the capacity of the UCSD Mother-Child-Adolescent HIV Program to participate in research directed toward behavioral, preventive, therapeutic and pathogenetic evaluation of HIV infected and at-risk adolescents through participation in the Adolescent Medicine Trials Network (ATN). The two major specific aims of this proposal are: 1) To extend the infrastructure in San Diego in order to expand the capacity of the UCSD Mother-Child-Adolescent Program to contribute significantly to all aspects of the ATN agenda; and 2) To help develop and implement studies within the ATN designed to: a)address behavioral, immunization and therapeutic strategies for the prevention of HIV infection of at-risk adolescents; b)examine behavioral, nutritional and treatment interventions to preserve health of adolescents with asymptomatic HIV infection; and c) examine behavioral, nutritional and treatment interventions to improve and sustain health of adolescents with symptomatic or immunologic impairment associated with their HIV infection. The UCSD Mother-Child-Adolescent Program is committed to participate in all aspects of the development of clinical trials for HIV-infected and at-risk adolescents. The experience of our team in HIV care, clinical trials and laboratory studies, we believe, will enable our group to make a significant contribution to the success of the ATN.

描述（由申请人提供）：青少年的艾滋病毒感染仍然是 美国和其他工业化国家的重大问题。全世界， 在所有新感染的人中，一半的年龄在15至24岁之间。 尽管在减少HIV的围产期传播方面取得了很大进展，但 对新感染的青少年的数量几乎没有影响 美国和被感染的青年人数在很大程度上未知。 识别艾滋病毒感染的青少年特别重要，是 在圣地亚哥的挑战甚至更大，这个城市与墨西哥接壤，拥有 世界上最经常越过国际边界。 UCSD母子 - 青少年艾滋病毒计划在开发方面取得了长足的进步 用于识别，护理和研究的全面基础设施 艾滋病毒感染的孕妇，儿童和青少年的参与。这 该应用程序的目标是扩大UCSD母子青春期的能力 艾滋病毒计划参与针对行为的研究， 预防性，治疗和致病性评估受感染的HIV和高危 青少年通过参加青少年医学试验 网络（ATN）。该提案的两个主要特定目的是：1）扩展 圣地亚哥的基础设施以扩大UCSD的能力 母子青少年计划为所有方面做出重大贡献 ATN议程； 2）帮助开发和实施ATN中的研究 设计为：a）解决行为，免疫和治疗策略 预防高危青少年的艾滋病毒感染； b）检查 行为，营养和治疗干预措施，以保护健康 无症状HIV感染的青少年； c）检查行为， 营养和治疗干预措施，以改善和维持 具有症状或免疫学障碍的青少年 艾滋病毒感染。 UCSD的母子青少年计划致力于 参与艾滋病毒感染的临床试验发展的各个方面 和处于危险的青少年。我们团队在艾滋病毒护理方面的经验， 我们认为，临床试验和实验室研究将使我们的小组能够 为ATN的成功做出重大贡献。