Midwest STD Cooperative Research Center

中西部性病合作研究中心

• 批准号: 6327374
• 负责人: Stanley M. Spinola
• 金额: $ 6.51万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6327374
• 关键词: cooperative study; sexually transmitted diseases

This is the second competitive renewal for the Midwest Sexual Transmitted Diseases Cooperative Research Center (STDCRC), a consortium agreement between Indiana University and Northwestern University Schools of Medicine. The primary objective of this Center is to focus the efforts of investigators with different scientific backgrounds and interests on STDs in such a way as to lead to new approaches to primary and secondary prevention. The Midwest STDCRC fosters productive, interdisciplinary, collaboration to enhance the capabilities of individual investigators and to stimulate the entry of other talented investigators into the field. The proposed projects include two focused on genital ulcer disease caused by herpes simplex virus and Haemophilus ducreyl. The first of these will evaluate viral and cellular requirements associated with entry of HSV-1 and HSV-2 into the genital tract using a mouse model of infection, and will also evaluate molecular mechanisms associated with dissemination to the nervous system. The second will utilize a human challenge model of infection to evaluate the role of the cutaneous immune response to H. ducreyl in pathogenesis. Two projects focus on different aspects of human papillomavirus (HPV) infections. One investigates mechanisms by which the E7 gene product of high risk HPV contributes to the development of anogenital malignancies. The second seeks to define the extent to which immunosuppression associated with transplantation of pregnancy results in reaction and expression of latent HPV infection; while a third project is focused on the mechanisms by which gene expression and replication of HPV are regulated by silencer and other genetic elements. Consistent with the objective primary prevention is a project which seeks to define the timing of recurrent sexually transmitted infections and their relationship to inter- and intra- personal factors which may modify the risk of recurrent infection. These projects will be supported by a Biostatistical Core, and a Clinical/Laboratory Core with the latter monitoring sexually transmitted diseases as biological markers for evidence of recurrent infection. This core will also collect specimens and data from individuals infected with different sexually transmitted pathogens and distribute them, along with appropriate clinical data, to the various projects. The extensive collaborations and cross-disciplinary fertilization which exists among the different projects will be reinforced by frequent scientific/administrative meetings to assess progress of each projects and provide constructive criticism and assistance.

这是中西部性传播疾病合作研究中心（STDCRC）的第二次竞争更新，这是印第安纳大学和西北大学医学院之间的财团协议。该中心的主要目的是将具有不同科学背景和兴趣的研究人员重点放在STD上，以导致新方法进行初级和次要预防的方法。中西部的股东股东大会促进了生产力，跨学科的合作，以增强个别调查人员的能力，并刺激其他有才华的研究人员进入该领域的能力。拟议的项目包括两个专注于由单纯疱疹病毒和嗜血杆菌引起的生殖器溃疡疾病。第一个将使用小鼠感染模型评估与将HSV-1和HSV-2进入生殖道相关的病毒和细胞需求，还将评估与传播到神经系统相关的分子机制。第二种将利用人类感染模型来评估皮肤免疫反应在发病机理中的作用。两个项目着重于人类乳头瘤病毒（HPV）感染的不同方面。一个人调查了高风险HPV的E7基因产物有助于肛门生态恶性肿瘤的发展的机制。第二种试图定义与妊娠移植相关的免疫抑制导致潜在HPV感染的反应和表达的程度；虽然第三个项目集中在基因表达和HPV复制的机制上，并由消音器和其他遗传元素调节。与客观预防相一致的是一个项目，该项目旨在定义反复发生的性传播感染的时间及其与个人间和内部因素的关系，这可能会改变反复感染的风险。这些项目将得到生物统计核心的支持，以及后者的临床/实验室核心，后者将性传播疾病作为生物学标志物，以证明复发性感染的证据。该核心还将收集感染不同性传播病原体的个体的标本和数据，并将其以及适当的临床数据分配给各种项目。在不同项目中存在的广泛合作和跨学科施肥将通过频繁的科学/行政会议来加强，以评估每个项目的进步并提供建设性的批评和援助。