MECHANISMS OF VISUAL CONTEXT EFFECTS IN VISUAL CORTEX

视觉皮层中视觉情境效应的机制

• 批准号: 6026978
• 负责人: JONATHAN B LEVITT
• 金额: $ 22万
• 依托单位: CITY COLLEGE OF NEW YORK
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6026978
• 关键词: Macaca fascicularis; Macaca mulatta; electrophysiology; ferrets; microelectrodes; neuroanatomy; neurons; space perception; synapses; visual cortex; visual fields; visual stimulus

Visual stimuli at locations beyond the classical receptive field (the area of the visual field from which responses can be evoked) can have profound effects on the selectivity and magnitude of neuronal responses in the visual cortex, even when these stimuli do not themselves evoke responses. It is generally assumed that intrinsic anatomical connections underlie these modulatory effects. Understanding how cortical neuron responses are shaped by such modulatory effects is important for understanding the role of cortical organization in determining cortical function, and in how the visual areas of the brain process complex real- world scenes. In this study we will clarify how neuronal responses in visual cortex are shaped by the spatial distribution of visual stimuli, and we will elucidate the anatomical substrates that link different points on the cortex (and therefore different spatial locations). This will therefore permit a direct test of whether local cortical connections do in fact underlie these modulatory surround effects. 1) In electrophysiological and neuroanatomical experiments in adult monkeys and ferrets, we will test whether the spatial extent and topography of response suppression or enhancement from beyond the classical receptive field can be accounted for by the distribution of local horizontal or cortical feedback connections within primary visual cortex (V1) and V2. 2) In electrophysiological studies in adult monkeys and ferrets, we will explore the stimulus specificity of response modulation from beyond the classical receptive field in V1 and V2. We will focus on V1 as the gateway to other cortical visual areas, but will also examine V2 to illuminate how general the properties and function of these modulatory effects are to all cortical visual areas. 3) In developmental studies in ferrets, we will systematically compare, across a large range of postnatal ages, the development of the modulatory surround effects to that of the responses in the classical receptive field, and to the refinement of intrinsic and extrinsic connections in V1. This will allow us to compare the developmental refinement of the modulatory effects to classical receptive field properties, and to further test whether intrinsic connections can underlie surround modulation. Comparison of details of the selectivity and spatial extent of different anatomical circuits with similar details from physiological investigations will provide information critical to an understanding of which anatomical circuits underlie particular functions, and in how neuronal function and connectivity underlie visual performance. This is a fundamental question in understanding how the cerebral cortex works, both in vision and in higher cognitive function.

经典感受野（可以引起反应的视野区域）之外的位置的视觉刺激可以对视觉皮层中神经元反应的选择性和幅度产生深远的影响，即使这些刺激本身不会引起反应。 通常认为内在的解剖学联系是这些调节作用的基础。 了解皮层神经元反应如何受到这种调节效应的影响，对于理解皮层组织在决定皮层功能以及大脑视觉区域如何处理复杂的现实世界场景中的作用非常重要。 在这项研究中，我们将阐明视觉皮层中的神经元反应如何受到视觉刺激的空间分布的影响，并且我们将阐明连接皮层上不同点（以及因此不同的空间位置）的解剖学基础。 因此，这将允许直接测试局部皮质连接是否确实是这些调制环绕效应的基础。 1）在成年猴子和雪貂的电生理学和神经解剖学实验中，我们将测试经典感受野之外的反应抑制或增强的空间范围和地形是否可以通过初级视觉内局部水平或皮层反馈连接的分布来解释皮质 (V1) 和 V2。 2) 在成年猴子和雪貂的电生理学研究中，我们将探索 V1 和 V2 经典感受野之外的反应调节的刺激特异性。 我们将重点关注 V1 作为通往其他皮质视觉区域的门户，但也会检查 V2 以阐明这些调节效应的属性和功能对所有皮质视觉区域的普遍性。 3) 在雪貂的发育研究中，我们将在大范围的出生后年龄系统地比较调节周围效应与经典感受野反应的发展，以及 V1 中内在和外在联系的细化。 这将使我们能够将调制效应的发展细化与经典感受野特性进行比较，并进一步测试内在连接是否可以成为环绕调制的基础。将不同解剖回路的选择性和空间范围的细节与生理学研究中的相似细节进行比较，将为理解哪些解剖回路构成特定功能以及神经元功能和连接性如何构成视觉表现提供关键信息。 这是理解大脑皮层在视觉和高级认知功能中如何工作的一个基本问题。