CONTROL AND CONSEQUENCES OF TIMING DEFICITS IN AGING

衰老时间缺陷的控制和后果

• 批准号: 6284860
• 负责人: BRIAN C RAKITIN
• 金额: $ 12.34万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6284860
• 关键词: Parkinson's disease; abnormal involuntary movement; adult human (21+); age difference; aging; behavior test; behavioral /social science research tag; choice; clinical research; cognition disorders; dopamine; human old age (65+); human subject; memory; mental process; neuropsychological tests; performance; stimulus /response; stimulus interval; time perception

DESCRIPTION (From the application): The proposed research explores the interval timing abilities of healthy older adults. Given the central role time plays in basic learning and memory, results of research into the cognitive and neural basis of timing dysfunction related to aging may lay the groundwork for better understanding of a wider range of age-related cognitive deficits. The proposed research has three objectives: (1) to determine whether timing is more easily disrupted by non-timing processing in older participants than in younger ones. This issue is addressed in two experiments that assess older subjects' performance with a dual-task method used previously to study college-aged students. This task combines aspects of choice reaction time and time production tasks, and allows for careful control of the difficulty of the non-timing task. Interference may result in changes to both timing accuracy and variability. (2) To compare and contrast performance of Parkinson's disease (PD) patients with that of healthy older adults on the tasks used in (1). Similarities among behavioral timing deficits in akinetic PD patients and older controls may indicate that dopamine depletion underlies deficits in both groups. (3) To determine whether aging impairs the processing of time in non-timing tasks. In warning signal paradigms, a signal indicates to the subject the impending arrival of an imperative stimulus. The duration of the warning signal partially determines the reaction time in young subjects. If age leads to impairment of a timing system that underlies temporal processing of the warning signal, then the reaction time of older subjects may be less affected by warning signal duration than the reaction time of younger subjects. The proposed training program will concentrate on skills necessary to conduct research on aged and neurologically impaired populations. This includes coursework, training in the administration of a variety of neuropsychological instruments, and observation and assessment on PD patients in a clinical setting.

描述（来自应用程序）：拟议的研究探讨了 健康老年人的间隔定时能力。 鉴于中心角色 时间在基本学习和记忆中发挥作用，研究结果 与衰老有关的时序功能障碍的认知和神经基础可能是 基础工作，以更好地理解更广泛的与年龄有关的认知 缺陷。 拟议的研究有三个目标：（1）确定 在较老的不合时宜的处理中，是否更容易破坏计时 参与者比年轻人。 这个问题在两个实验中解决了 通过使用的双重任务方法评估较旧受试者的性能 以前要学习大学生。 此任务结合了 选择反应时间和时间生产任务，并允许仔细控制 不合时宜的任务的困难。 干扰可能会导致变化 达到定时准确性和可变性。 （2）比较和对比 帕金森氏病（PD）患者的表现健康 成人（1）中使用的任务。 行为时机之间的相似之处 Akinetic PD患者和较旧对照的缺陷可能表明多巴胺 两组的耗竭是两组缺陷的基础。 （3）确定是否衰老 损害非定时任务中时间的处理。 在警告信号中 范式，一个信号指示主题即将到来 势在必行的刺激。 警告信号的持续时间部分确定 年轻受试者的反应时间。 如果年龄导致时间损害 警告信号的时间处理的系统，然后 较老受试者的反应时间可能会受到警告信号的影响较小 持续时间比年轻受试者的反应时间。 拟议的培训 计划将集中于对老年人进行研究所必需的技能 神经系统受损的人群。 这包括课程工作，培训 管理各种神经心理学工具，以及 在临床环境中对PD患者的观察和评估。