MOTOR CONTROL AND MOTOR UNIT RECRUITMENT

电机控制和电机单元招募

基本信息

批准号：
2735491
负责人：
ARON S BUCHMAN
金额：
$ 9.02万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-09-30 至 1999-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2735491
关键词：
Parkinson's disease abnormal involuntary movement aging body physical characteristic central nervous system degenerative motor system disease electromyography human old age (65+) human subject motor neurons muscle contraction nervous system disorder neuromuscular system psychomotor disorders psychomotor function stroke young adult human (21-34)

项目摘要

This proposal will investigate central motor control mechanisms that underlie voluntary movement. Central control of motor activity is expressed through activation of the peripheral muscles. While the central nervous system activity underlying voluntary movement cannot be directly measured, peripheral muscle activity can be measured. The Dual Strategy Hypothesis, which models central motor control for single-joint movements, was developed through recordings of surface electromyography. This hypothesis describes two classes of motor tasks which we will test in three experiments. Two distinct but complementary techniques, conventional surface electromyography and motor unit action potentials, will be used to measure muscle activity to elucidate central motor control. Experiment 1 will determine the effect of aging on voluntary motor control by comparing the patterns of surface electromyography in healthy aged subjects and young subjects performing Dual Strategy motor tasks. Experiment 2 will characterize the patterns of motor unit recruitment which underlie the surface electromyographic recordings of the Dual Strategy motor tasks in young subjects. Precision Decomposition EMG will be employed to decompose the constituent motor unit action potentials which underlie the Dual Strategy motor tasks in young subjects. Experiment 3 will define some of the effects of aging and central motor disorders on patterns of surface electromyography and motor unit recruitment. The techniques used in experiments 1 & 2 will be applied to healthy aged subjects and compared with results observed in two central motor disorders: Parkinson's disease and stroke. This proposal will lead to the development of techniques that provide simultaneous kinetic, kinematic, surface electromyography and motor unit recruitment pattern descriptions of motor activity. This will enhance studies which seek to elucidate the physiology of normal and abnormal motor activity. Clinical application of these techniques will broaden the focus of conventional electromyography to include quantitative measures of motor unit recruitment and firing and also allow electromyographic assessment of central motor disorders. These techniques could be used to provide objective measures for evaluating motor dysfunction and monitoring therapeutic interventions. In addition, these techniques may be useful for detecting presymptomatic central motor disorders.

该建议将调查中央运动控制机制基础自愿运动。运动活动的中心控制是通过激活周围肌肉表达。而中央自愿运动的基础神经系统活动不能直接可以测量测量的周围肌肉活动。双重策略假设，该假设为单关节运动建模中央电动机控制，是通过表面肌电图的记录开发的。这假设描述了我们将在三个实验。两种不同但互补的技术，传统表面肌电图和运动单位动作电位将用于测量肌肉活动以阐明中央运动控制。实验1将确定衰老对自愿运动控制的影响通过比较健康老化的表面肌电图的模式受试者和年轻受试者执行双重策略运动任务。实验2将表征运动单元募集的模式这是双重表面肌电记录的基础年轻受试者的策略运动任务。精确分解EMG将被用来分解组成运动单位动作电位这是年轻受试者双重战略运动任务的基础。实验 3将定义衰老和中央运动障碍的某些影响表面肌电图和运动单元募集的模式。这实验1和2中使用的技术将应用于健康的老年受试者并将其与在两个中央电动机中观察到的结果进行了比较疾病：帕金森氏病和中风。该建议将导致提供提供的技术同时动力学，运动学，表面肌电图和运动单元运动活动的招聘模式描述。这将增强试图阐明正常和异常生理的研究运动活动。这些技术的临床应用将扩大常规肌电图的重点，包括定量度量运动单元招募和射击，还允许肌电图评估中央运动障碍。这些技术可用于提供评估电动机功能障碍和监测的客观措施治疗干预措施。另外，这些技术可能对检测预症状的中枢运动障碍。