MOTOR CONTROL AND MOTOR UNIT RECRUITMENT

电机控制和电机单元招募

• 批准号: 2259517
• 负责人: ARON S BUCHMAN
• 金额: $ 7.4万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2259517
• 关键词: Parkinson's disease; abnormal involuntary movement; aging; body physical characteristic; central nervous system; degenerative motor system disease; electromyography; human old age (65+); human subject; motor neurons; muscle contraction; nervous system disorder; neuromuscular system; psychomotor disorders; psychomotor function; stroke; young adult human (21-34)

This proposal will investigate central motor control mechanisms that underlie voluntary movement. Central control of motor activity is expressed through activation of the peripheral muscles. While the central nervous system activity underlying voluntary movement cannot be directly measured, peripheral muscle activity can be measured. The Dual Strategy Hypothesis, which models central motor control for single-joint movements, was developed through recordings of surface electromyography. This hypothesis describes two classes of motor tasks which we will test in three experiments. Two distinct but complementary techniques, conventional surface electromyography and motor unit action potentials, will be used to measure muscle activity to elucidate central motor control. Experiment 1 will determine the effect of aging on voluntary motor control by comparing the patterns of surface electromyography in healthy aged subjects and young subjects performing Dual Strategy motor tasks. Experiment 2 will characterize the patterns of motor unit recruitment which underlie the surface electromyographic recordings of the Dual Strategy motor tasks in young subjects. Precision Decomposition EMG will be employed to decompose the constituent motor unit action potentials which underlie the Dual Strategy motor tasks in young subjects. Experiment 3 will define some of the effects of aging and central motor disorders on patterns of surface electromyography and motor unit recruitment. The techniques used in experiments 1 & 2 will be applied to healthy aged subjects and compared with results observed in two central motor disorders: Parkinson's disease and stroke. This proposal will lead to the development of techniques that provide simultaneous kinetic, kinematic, surface electromyography and motor unit recruitment pattern descriptions of motor activity. This will enhance studies which seek to elucidate the physiology of normal and abnormal motor activity. Clinical application of these techniques will broaden the focus of conventional electromyography to include quantitative measures of motor unit recruitment and firing and also allow electromyographic assessment of central motor disorders. These techniques could be used to provide objective measures for evaluating motor dysfunction and monitoring therapeutic interventions. In addition, these techniques may be useful for detecting presymptomatic central motor disorders.

该提案将研究中央电机控制机制 是自愿运动的基础。运动活动的中枢控制是 通过周围肌肉的激活来表达。虽然中央 随意运动背后的神经系统活动不能直接被 测量时，可以测量周围肌肉的活动。双重战略 假设，模拟单关节运动的中央运动控制， 是通过表面肌电图记录开发的。这 假设描述了我们将测试的两类运动任务 三个实验。两种不同但互补的技术，传统的 表面肌电图和运动单位动作电位，将用于 测量肌肉活动以阐明中枢运动控制。 实验 1 将确定衰老对自主运动控制的影响 通过比较健康老年人的表面肌电图模式 执行双重策略运动任务的受试者和年轻受试者。 实验 2 将描述运动单位募集模式的特征 这是 Dual 表面肌电图记录的基础 年轻受试者的策略运动任务。精密分解肌电图将 用于分解组成运动单位动作电位 这是年轻受试者双重策略运动任务的基础。实验 3 将定义衰老和中枢运动障碍对身体的一些影响 表面肌电图和运动单位招募的模式。这 实验 1 和 2 中使用的技术将应用于健康老年人 受试者并与两个中枢运动观察到的结果进行比较 疾病：帕金森病和中风。 该提案将导致技术的发展，提供 同步动力学、运动学、表面肌电图和运动单元 运动活动的招募模式描述。这将增强 旨在阐明正常和异常生理学的研究 运动活动。这些技术的临床应用将拓宽 传统肌电图的重点包括定量测量 运动单位募集和发射，还允许肌电图 中枢运动障碍的评估。这些技术可用于 提供评估运动功能障碍和监测的客观措施 治疗干预。此外，这些技术可能有助于 检测症状前中枢运动障碍。