Prevention of Hip Dysplasia with Thermal Energy

用热能预防髋关节发育不良

• 批准号: 6324250
• 负责人: MANDI J. LOPEZ
• 金额: $ 10.26万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6324250
• 关键词: articular cartilage; biomarker; biomechanics; chondroitin sulfates; collagen; computed axial tomography; disease /disorder prevention /control; dogs; enzyme linked immunosorbent assay; gene expression; hip; hyperthermia therapy; joint disorder; longitudinal animal study; mucopolysaccharides; nonhuman therapy evaluation; osteoarthritis; polymerase chain reaction; proteoglycan; radiography; radioimmunoassay; radiowave radiation; synovial fluid; viscosity

The fundamental goals of this research proposal are to test the hypotheses that: 1) application of thermal energy at 65 degrees C using radio-frequency energy to the coxofemoral joint capsule of puppies with radiographic evidence of joint laxity will result in normal hip congruity, 2) will prevent the development of the lameness and the cartilagenous and bony changes characteristic of CHD, and 3) will not have detrimental effects on the biomechanical or viscoelastic properties of the joint capsular tissue. These investigations will yield insights into the fundamental mechanisms of thermal modification of musculoskeletal soft tissue. This research program is designed to determine whether thermal modification of coxocofemoral joint capsule of 16-week-old puppies with excessive joint: laxity will prevent CHD. Ultimately, this model will serve to evaluate the potential of thermal energy to reduce excessively lax coxofemoral joints in neonatal children and thereby help prevent DDH. The candidate of this application graduated magna cum laude from Humboldt State University with a B.S. in cellular-molecular biology and a minor in chemistry. She worked as a molecular biologist at Amgen, Thousand Oaks, CA, before undertaking and; completing her D.V.M. at the University of California-Davis. Dr. Lopez was awarded 5 scholarships and 2 research grants while a D.V.M. student. She completed an internship at Kansas State University and a large animal surgery residency/Master's degree at they University of Wisconsin- Madison. She is a board certified large animal surgeon. Dr. Lopez's Master's thesis was entitled "Effects of Radio-frequency Energy on Ovine Stifle Joint Capsule", and she performed much of the early radio- frequency work in the Comparative Orthopaedic Research Laboratory. She was awarded an NRSA in 1998 and has performed the background research and preliminary, studies that form the basis for this proposal. She passed her preliminary examinations "With Honors" in November, 1999, and is scheduled to complete her PhD in June 2001. Her ultimate goal is to join the faculty of an academic institution as a well-trained scientist and productive researcher specializing in integrative, translational research. The training environment will be guided toward mentoring the candidate while teaching valuable research techniques necessary to begin an independent research career. The majority of supervision will be provided by Mark D. Markel, an internationally known and respected investigator in the area of thermal tissue modification, Professor of Surgery, and Professor and Chairman of Medical Sciences. The advisory committee will consist of well-respected and highly experienced individuals within the University. The Comparative Orthopaedic Research Laboratory is a well established laboratory that houses multi- disciplinary research programs. The University of Wisconsin provides an exceptional environment for interaction with experts in a variety of fields, and it is well known for its exceptional research programs, especially in the medical sciences.

这项研究建议的基本目标是测试以下假设：1）使用射频能量在65度C下应用热能在幼犬的Coxofemoral关节囊上具有关节静脉鼻涕的放射线证据，将导致正常的髋关节一致性；关节囊组织的生物力学或粘弹性。这些研究将洞悉肌肉骨骼软组织热修饰的基本机制。该研究计划旨在确定对关节过度的16周龄幼犬的coxofemoral关节胶囊的热修饰：松弛会阻止CHD。最终，该模型将有助于评估热能的潜力，以减少新生儿儿童中过度松弛的Coxofemoral关节，从而有助于预防DDH。该申请的候选人毕业于洪堡州立大学，以学士学位为单位。在细胞分子生物学和化学辅修中。在进行之前，她曾在加利福尼亚州千橡市的Amgen生物学家担任分子生物学家。完成她的D.V.M.在加利福尼亚大学戴维斯大学。洛佩兹博士获得了5项奖学金和2项研究补助金，而D.V.M.学生。她在堪萨斯州立大学完成了实习，并在威斯康星大学 - 麦迪逊大学获得了大型动物外科/硕士学位。她是董事会认证的大型动物外科医生。洛佩兹博士的硕士论文的标题为“射频能量对卵子窒息关节囊的影响”，她在比较骨科研究实验室中进行了许多早期的放射频率工作。她在1998年获得了NRSA授予，并进行了背景研究和初步研究，这是该提案的基础。她在1999年11月通过了“荣誉”的初步考试，并计划在2001年6月完成博士学位。她的最终目标是加入学术机构学院，成为一名训练有素的科学家和生产性研究人员，专门研究综合性，翻译研究。培训环境将被指导指导候选人，同时教授开始独立研究职业所需的宝贵研究技术。大多数监督将由国际知名和受人尊敬的研究员马克·D·马克尔（Mark D.咨询委员会将由大学内备受尊敬和经验丰富的个人组成。比较骨科研究实验室是一个拥有多学科研究计划的知名实验室。威斯康星大学为与各个领域的专家互动提供了一个非凡的环境，并且以其出色的研究计划而闻名，尤其是在医学科学领域。