DYNAMICAL STUDIES IN TEMPORAL AND FRONTAL LOBE EPILEPSY

颞叶和额叶癫痫的动力学研究

• 批准号: 6187914
• 负责人: James Chris Sackellares
• 金额: $ 15.3万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-01-30 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6187914
• 关键词: brain disorder diagnosis; brain electrical activity; clinical research; electroencephalography; hippocampus; human subject; partial seizure; temporal lobe /cortex disorder

The proposed research is based upon three key discoveries made during the initial funding period of this project. These discoveries resulted from the application of nonlinear analytic techniques to the study of intracranial electroencephalographic (EEG) recordings performed in patients with medically intractable seizures of anterior mesial temporal (AMT) origin. First, in the interictal state, signals generated by the epileptogenic AMT focus exhibit dynamical characteristics that distinguish them from those recorded from other areas of the hippocampus and cerebral cortex. This discovery offers the possibility of improved methods for localizing the epileptogenic focus, obviating the need to record multiple seizures, and identifying patients that are most likely to experience seizure control following surgery. Second, AMT seizures are preceded by a characteristic spatiotemporal transition process that begins up to l hour prior to the initial ictal discharge. This transition involves dynamical entrainment of multiple areas of both cerebral hemispheres and can be demonstrated with measures of spatiotemporal order or chaos (e.g., maximum Lyapunov exponent). The presence of a preictal transition process offers the potential for predicting seizure occurrence in time to prevent an impending seizure through novel therapeutic interventions. Third, preictal entrainment similar to that observed in AMT foci has been observed in a few cases with orbitofrontal foci. The first aim of the present proposal is to examine recordings from patients with a single unilateral AMT epileptogenic focus to determine whether the epileptogenic focus can be identified consistently and accurately with dynamical measures of the interictal EEG. In contrast, we postulate that recordings from patients with two or more independent epileptogenic foci will not demonstrate a single dynamically distinct focus in the interictal state. The second aim is to determine whether temporal lobe seizures can be predicted using algorithms designed to detect preictal transition to the seizure. Finally, we wish to test the hypothesis that seizures originating in the frontal or temporal neocortex are consistently preceded by a spatiotemporal dynamical transition similar to that observed in seizures of AMT origin.

拟议的研究基于在 该项目的初始资金期。这些发现来自 非线性分析技术在研究中的应用 颅内脑电图（EEG）记录 前介体颞叶的医学上顽固性癫痫发作的患者 （AMT）起源。首先，在发作状态下，该信号由 癫痫发作AMT焦点具有区分动力学特征 它们来自海马和大脑其他区域的记录 皮质。该发现为改进方法提供了改进的方法 定位癫痫焦点，消除了记录多个的需求 癫痫发作，并确定最有可能体验的患者 手术后的癫痫发作控制。其次，AMT癫痫发作之前是 特征性时空过渡过程，最高为l小时 在初始发作之前。这种过渡涉及动态 夹带两个脑半球的多个区域，可以是 用时空秩序或混乱的度量证明（例如，最大 Lyapunov指数）。前过渡过程的存在 预测时间的癫痫发作的潜力，以防止 即将通过新的治疗干预措施癫痫发作。第三，perictal 在A中观察到了与AMT焦点相似的夹带 轨道额焦点很少。本提议的第一个目的 是检查单个单侧AMT患者的记录 癫痫发作的重点以确定癫痫发生焦点是否可以是 通过动态测量的始终准确地确定 临时脑电图。相反，我们假设患者的记录 具有两个或多个独立的癫痫病灶不会证明 截期性状态下，单个动态截然不同的重点。第二个目标 是确定是否可以使用颞叶癫痫发作 旨在检测癫痫发作过渡的算法。最后， 我们希望检验以下假设，即癫痫发作起源于额叶或 颞新皮层始终先于时空动力学 过渡类似于在AMT起源癫痫发作中观察到的过渡。