EFFECTS OF PHYSIOLOGICAL ACTIVATION ON BRAIN ELECTRICAL PATTERNS

生理活动对脑电模式的影响

• 批准号: 7605495
• 负责人: James Chris Sackellares
• 金额: $ 1.18万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-23 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605495
• 关键词: Area; Brain; Cerebral cortex; Characteristics; Computer Retrieval of Information on Scientific Projects Database; Condition; Development; Electrodes; Electroencephalography; Funding; Grant; Institution; Measurable; Measures; Partial Epilepsies; Patients; Pattern; Physiological; Pilot Projects; Research; Research Personnel; Resolution; Resources; Seizures; Signal Transduction; Source; Testing; United States National Institutes of Health; Vagus nerve structure; improved; indexing; spatiotemporal; vagus nerve stimulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Vagus nerve stimulation (VNS) has been shown to improve seizure control in patients with intractable partial epilepsy. However, the mechanism of action is not known. Previous studies have indicated that the development and resolution of seizures are associated with measurable changes in the spatiotemporal dynamics of EEG signals. We propose to conduct a pilot study to analyze the effect of vagus nerve stimulation on the dynamical characteristics of EEG signals. Specifically, we will test the hypothesis that activation of the vagus nerve stimulator, under specific dynamical conditions, will cause the EEG dynamics to return to state in which seizures are less likely to occur. This state is characterized by higher values of the T-index, a measure indicating lower dynamical similarity in the EEG signal derived from electrodes located over widespread areas of the cerebral cortex.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 迷走神经刺激（VNS）已被证明可以改善顽固性部分癫痫患者的癫痫发作控制。但是，作用机理尚不清楚。先前的研究表明，癫痫发作的发展和分辨率与脑电信号时空动力学的可测量变化有关。 我们建议进行一项试验研究，以分析迷走神经刺激对脑电图信号动力学特征的影响。 具体而言，我们将检验以下假设：在特定的动力条件下，迷走神经刺激剂的激活将导致脑电图恢复到癫痫发作的可能性较小的状态。该状态的特征是T索引的较高值，这是一种指示较低的脑电图信号的量度，这些脑电图来自位于大脑皮层广泛区域的电极。