Preclinical Core

临床前核心

基本信息

批准号：
10455491
负责人：
SHERYL S MOY
金额：
$ 31.94万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-28 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10455491
关键词：
Angelman Syndrome Animal Model Architecture Ataxia Atlases Attention deficit hyperactivity disorder Automatic Data Processing Behavior Behavioral Biological Assay Brain Brain imaging CRISPR/Cas technology Caliber Center for Translational Science Activities Childhood Clinical Cognitive Consultations Contrast Media Core Facility Data Data Analytics Data Science Core Diagnosis Drug Screening Electrophysiology (science)Embryo Epilepsy Evaluation Faculty Functional disorder Genes Genetic Goals Grain Human Image Imaging Device In Vitro Infrastructure Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Intervention Joubert syndrome Laboratories Machine Learning Magnetic Resonance Imaging Maps Measurement Methods Microscopy Microtus Modeling Molecular Morphology Motor Mus Neonatal Neurobiology Neurodevelopmental Disorder Neuroglia Neurons Neurosciences Phenotype Photosensitivity Pitt-Hopkins syndrome Pre-Clinical Model Prevention Regimen Research Research Personnel Research Training Resolution Resources Rett Syndrome Science Sensory Services Social Functioning Source Structure-Activity Relationship Students Supervision System Techniques Technology Testing Time Tissues Training Work animal imaging behavior test behavioral phenotyping behavioral response brain behavior brain cell brain volume cognitive function data access data analysis pipeline developmental disease drug discovery efficacy testing electrical microstimulation emotional functioning genome editing improved in vivo innovation laboratory experience laboratory facility member method development migration model development mouse genetics mouse model multi-electrode arrays multidisciplinary multiphoton imaging neural circuit neurodevelopment neuroimaging novel optogenetics phenotypic biomarker pre-clinical relating to nervous system spatiotemporal translational neuroscience

项目摘要

Preclinical Core Abstract The Preclinical Core (PC) provides IDDRC investigators with innovative, advanced approaches to conduct research spanning fine-grained resolution at the molecular and cellular level, to regional neurocircuitry and connectivity across brain, to multi-domain characterization of mouse behavior. In this application, 40 projects from 21 IDDRC investigators are proposed for core access in studies using models of ADHD, Angelman syndrome, ASD, childhood ataxia, epilepsy, intellectual disability, Joubert syndrome, Pitt-Hopkins syndrome, Rett syndrome, and other neurodevelopmental disorders. The PC has three components, the Mouse Behavioral Phenotyping Laboratory, the Neuroscience Microscopy Facility, and the Small Animal Imaging Service, which, together, offer a broad range of resources and expertise for multidisciplinary IDD research. Services include consultation with expert core faculty, an extensive battery of mouse behavioral testing, training in cutting-edge microscopy methods, acquisition and analysis of quantitative MRI data, and access to state-of-the-art laboratory facilities. A critical goal for the Core is to facilitate projects integrating complementary approaches, such as microscopy analysis of cortical architecture and behavioral evaluation of cognitive phenotypes, to enhance understanding of underlying pathophysiology and structure-function relationships in neurodevelopmental disorders. Within the IDDRC, the PC partners with the Clinical Translational Core and Data Science Core around the use of machine-learning approaches and the establishment of automated data-processing pipelines for new methods development. Overall, the PC provides expertise and infrastructure that has become essential for our IDDRC research using preclinical models, with the overarching aim of supporting breakthrough, transformative science in diagnosis, prevention, and treatment of developmental disorders. 1

临床前核心摘要临床前核（PC）为IDDRC调查人员提供了创新的高级行为方法研究涵盖分子和细胞水平的细粒分辨率，区域神经记录和跨大脑的连通性，与小鼠行为的多域表征。在此应用程序中，有40个项目从21位IDDRC调查人员提出了使用ADHD模型，Angelman的研究中的核心访问综合征，ASD，儿童共济失调，癫痫，智力残疾，乔伯特综合征，皮特 - 霍普金斯综合征， RETT综合征和其他神经发育障碍。 PC有三个组件，鼠标行为表型实验室，神经科学显微镜设施和小动物成像服务共同为多学科IDD研究提供了广泛的资源和专业知识。服务包括与专家核心教师的咨询，大量的鼠标行为测试，在尖端显微镜方法中培训，对定量MRI数据的获取和分析以及访问最先进的实验室设施。核心的关键目标是促进项目集成互补方法，例如皮质结构的显微镜分析和行为评估认知表型，以增强对潜在的病理生理和结构功能的理解神经发育障碍的关系。在IDDRC中，PC与临床合作转化核心和数据科学核心围绕使用机器学习方法和建立用于新方法开发的自动数据处理管道。总体而言，PC 提供专业知识和基础架构，这对于使用临床前的IDDRC研究至关重要模型，以支持突破性，诊断，预防的变革性科学的总体目的和发育障碍的治疗。 1