Preclinical Core

临床前核心

基本信息

批准号：
10673853
负责人：
SHERYL S MOY
金额：
$ 31.94万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-28 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10673853
关键词：
Angelman Syndrome Animal Model Architecture Ataxia Atlases Attention deficit hyperactivity disorder Automatic Data Processing Behavior Behavioral Biological Assay Biological Markers Brain Brain imaging Brain region CRISPR/Cas technology Caliber Cells Center for Translational Science Activities Childhood Cognitive Consultations Contrast Media Core Facility Data Data Analytics Data Science Core Diagnosis Drug Screening Electrophysiology (science)Embryo Epilepsy Evaluation Faculty Functional disorder Genes Genetic Goals Grain Human Image Imaging Device In Vitro Infrastructure Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Intervention Joubert syndrome Laboratories Machine Learning Magnetic Resonance Imaging Maps Measurement Methods Microscopy Microtus Modeling Molecular Morphology Motor Mus Neonatal Neurobiology Neurodevelopmental Disorder Neuroglia Neurons Neurosciences Phenotype Pitt-Hopkins syndrome Pre-Clinical Model Prevention Regimen Research Research Personnel Resolution Resources Rett Syndrome Science Sensory Services Social Functioning Source Structure-Activity Relationship Students System Techniques Testing Time Tissues Training Work animal imaging behavior test behavioral phenotyping behavioral response brain behavior brain volume clinical translation cognitive function data analysis pipeline developmental disease drug discovery efficacy testing electrical microstimulation emotional functioning genetic technology genome editing improved in vivo innovation laboratory experience laboratory facility member method development migration model development mouse genetics mouse model multi-electrode arrays multi-photon multidisciplinary multiphoton imaging neural neural circuit neurodevelopment neuroimaging novel optogenetics pre-clinical spatiotemporal translational neuroscience

项目摘要

Preclinical Core Abstract The Preclinical Core (PC) provides IDDRC investigators with innovative, advanced approaches to conduct research spanning fine-grained resolution at the molecular and cellular level, to regional neurocircuitry and connectivity across brain, to multi-domain characterization of mouse behavior. In this application, 40 projects from 21 IDDRC investigators are proposed for core access in studies using models of ADHD, Angelman syndrome, ASD, childhood ataxia, epilepsy, intellectual disability, Joubert syndrome, Pitt-Hopkins syndrome, Rett syndrome, and other neurodevelopmental disorders. The PC has three components, the Mouse Behavioral Phenotyping Laboratory, the Neuroscience Microscopy Facility, and the Small Animal Imaging Service, which, together, offer a broad range of resources and expertise for multidisciplinary IDD research. Services include consultation with expert core faculty, an extensive battery of mouse behavioral testing, training in cutting-edge microscopy methods, acquisition and analysis of quantitative MRI data, and access to state-of-the-art laboratory facilities. A critical goal for the Core is to facilitate projects integrating complementary approaches, such as microscopy analysis of cortical architecture and behavioral evaluation of cognitive phenotypes, to enhance understanding of underlying pathophysiology and structure-function relationships in neurodevelopmental disorders. Within the IDDRC, the PC partners with the Clinical Translational Core and Data Science Core around the use of machine-learning approaches and the establishment of automated data-processing pipelines for new methods development. Overall, the PC provides expertise and infrastructure that has become essential for our IDDRC research using preclinical models, with the overarching aim of supporting breakthrough, transformative science in diagnosis, prevention, and treatment of developmental disorders. 1

临床前核心摘要临床前核心 (PC) 为 IDDRC 研究人员提供创新、先进的方法来进行研究范围涵盖分子和细胞水平的细粒度分辨率、区域神经回路和跨大脑的连接，到小鼠行为的多域表征。在此应用程序中，有 40 个项目 21 名 IDDRC 研究者被提议使用 ADHD、Angelman 模型进行研究的核心访问综合征、自闭症谱系障碍、儿童共济失调、癫痫、智力障碍、朱伯特综合征、皮特-霍普金斯综合征、雷特综合征和其他神经发育障碍。 PC由三个组件组成，鼠标行为表型实验室、神经科学显微镜设施和小动物成像服务，共同为多学科 IDD 研究提供广泛的资源和专业知识。服务包括与专家核心教师的咨询、广泛的小鼠行为测试、尖端显微镜方法、定量 MRI 数据采集和分析以及获取最先进的实验室设施。核心的一个关键目标是促进项目集成补充方法，例如皮层结构的显微镜分析和行为评估认知表型，增强对潜在病理生理学和结构功能的理解神经发育障碍的关系。在 IDDRC 内，PC 与临床部门合作围绕机器学习方法和技术的使用的转化核心和数据科学核心为新方法开发建立自动化数据处理管道。总体而言，PC 提供专业知识和基础设施，这对于我们使用临床前的 IDDRC 研究至关重要模型，其总体目标是支持诊断、预防、和发育障碍的治疗。 1