ALCOHOL IN RISK BEHAVIORS AND NEUROBEHAVIORAL STATUS

酒精对危险行为和神经行为状态的影响

• 批准号: 6168685
• 负责人: HECTOR FRANKLIN MYERS
• 金额: $ 10.02万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6168685
• 关键词: African American; HIV infections; alcoholic beverage consumption; alcoholism /alcohol abuse; behavioral /social science research tag; brain circulation; clinical research; cognition; communicable disease transmission; disease /disorder proneness /risk; drug abuse; high risk behavior /lifestyle; human immunodeficiency virus; human subject; magnetic resonance imaging; male; neuroregulation; nuclear magnetic resonance spectroscopy; sex behavior; single photon emission computed tomography; social psychology; substance abuse related behavior

DESCRIPTION (adapted from the Abstract): Preliminary results from this research team suggest that contrary to expectations, neurocognitive deficits among African American men infected with HIV-1 are related to alcohol consumption, but not to the use of cocaine. In this application, the Principal Investigator proposes to follow-up on those initial findings with a series of focused secondary analyses on the very rich dataset collected in the NIDA-funded African American Health Project (AAHP). The study is designed to examine the neurobehavioral effects of HIV/AIDS and substance use in a community sample of HIV-positive and HIV-negative African American men, arguably the largest community sample of high-risk African American who have been assessed with a comprehensive neurobiological, psychiatric, and psychosocial measures. Two parallel studies are proposed in this application. In Study #1, the researchers will examine the contribution of alcohol to high risk sexual behaviors, both independently and as modified by illicit drug use and other psychosocial co-factors in a sample of 190 HIV-positive and 312 HIV-negative men. In Study #2, they will examine the contribution of alcohol to neurocognitive functioning and neurcognitive caseness in the full sample of 502 men. The researchers will examine, also, the role of alcohol in neurophysiologic status and functioning as indexed by regional blood flow (rCBF) in a stratified sample of 118 HIV-positive and HIV-negative men using state-of-the-art neuroimaging techniques (MRI, MRS, SPECT). In these analyses, the researchers will take advantage of a unique dataset using, thereby, a relatively cost- effective means to enhance our understanding of the role alcohol plays in HIV disease in this understudied population.

描述（改编自摘要）：初步结果 研究小组认为，与预期相反，神经认知 感染 HIV-1 的非洲裔美国男性的缺陷与 饮酒，但不宜使用可卡因。在这个应用程序中， 首席研究员建议对这些初步调查采取后续行动 对富人进行一系列集中二次分析的结果 NIDA 资助的非裔美国人健康项目收集的数据集 （AAHP）。该研究旨在检查神经行为的影响 艾滋病毒/艾滋病和艾滋病毒阳性社区样本中的药物使用 艾滋病毒阴性的非洲裔美国男性，可以说是最大的社区样本 接受过评估的高风险非裔美国人 全面的神经生物学、精神病学和社会心理测量。 本申请提出了两项​​平行研究。在研究#1 中， 研究人员将研究酒精对高风险性行为的影响 行为，无论是独立的还是因非法药物使用而改变的 190 名 HIV 阳性样本和 312 名样本中的其他社会心理辅助因素 艾滋病毒阴性男性。在研究#2 中，他们将研究以下方面的贡献： 酒精对神经认知功能和神经认知案例的影响 502 名男性的完整样本。研究人员还将研究 酒精对神经生理状态和功能的影响 118 名 HIV 阳性患者的分层样本中的局部血流量 (rCBF) 和艾滋病毒阴性男性使用最先进的神经影像技术 （MRI、MRS、SPECT）。在这些分析中，研究人员将采取 利用独特的数据集的优势，从而相对成本 增强我们对酒精作用的了解的有效方法 在这个未被充分研究的人群中，艾滋病毒疾病的发病率。