DENTAL FEAR AND ANTICIPATION OF PAIN: IMAGING THE BRAIN

对牙科的恐惧和对疼痛的预期：大脑成像

• 批准号: 6258077
• 负责人: Margaret M Bradley
• 金额: $ 19.62万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-15 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6258077
• 关键词: brain circulation; brain imaging /visualization /scanning; brain mapping; clinical research; fear; gender difference; human subject; magnetic resonance imaging; psychophysiology

DESCRIPTION: The proposed experimental program is designed to assess changes in brain function that occur with fearful anticipation of a painful stimulus. Its principal aim is to determine the relationship between activity in specific brain structures (as defined by changes in regional blood flow), reports of fear arousal, and the electrocortical, visceral, and somatic responses that occur when expecting a painful stimulus. This research is driven by a motivational theory of human emotion that is founded on behavioral, psychophysiological, and neurophysiological research. The proposed studies are intended to explicate neural mechanisms that mediate fear of pain in normal humans, and furthermore, to examine possible individual differences in anticipation of pain between men and women, and between those who are low or high in dental fear. The specific aim of the proposed research is to map neural activation in the brain during fearful anticipation evoked by imminent painful stimulation, and to relate the obtained brain maps to psychophysiological patterns of fear reactivity. Three primary independent variables are assessed: 1) The type of anticipated stimulus (electric shock or nonpainful vibrotactile); 2) Dental fear level of the subject (low, high); and 3) Sex of the subject. Each of these eight studies (2 stimulus type x 2 fear groups x 2 sex) will be conducted once in the magnetic resonance imaging (MRI) context to assess functional brain activity, and once (with new participants) in a simulated MRI context to acquire autonomic, somatic, and central (i.e., EEG) physiological measures of anticipatory fear. The proposed research will address questions concerning the neural and psychophysiological organization of fear associated with imminent pain, as well as how individual differences in fear and/or sex affect these reactions. The proposed methodology is, furthermore, adaptable and can be used subsequently to address other facets (sensory and emotional) of the pain experience.

描述：拟议的实验计划旨在评估 大脑功能因对痛苦刺激的恐惧预期而发生。它是 主要目的是确定特定活动之间的关系 大脑结构（由区域血流的变化定义），报告 恐惧唤起，以及皮层、内脏和躯体反应 当期待痛苦的刺激时就会发生。这项研究是由 人类情感的动机理论建立在行为、 心理生理学和神经生理学研究。拟议的研究是 旨在解释介导正常人对疼痛的恐惧的神经机制 人类，并进一步检查可能的个体差异 男性和女性之间以及低等或低等人之间对疼痛的预期 高度恐惧牙科。该研究的具体目标是绘制神经网络图 当即将发生的疼痛引起恐惧预期时，大脑会被激活 刺激，并将获得的大脑图谱与心理生理学联系起来 恐惧反应的模式。评估三个主要自变量： 1) 预期刺激的类型（电击或无痛性刺激） 振动触觉）； 2) 受试者对牙科的恐惧程度（低、高）； 3) 性别 主题。这八项研究中的每一项（2 个刺激类型 x 2 个恐惧组 x 2 性）将在磁共振成像（MRI）背景下进行一次 评估功能性大脑活动，并且一次（与新参与者一起） 模拟 MRI 环境以获取自主神经、躯体神经和中枢神经（即脑电图） 预期恐惧的生理测量。拟议的研究将解决 有关恐惧的神经和心理生理组织的问题 与迫在眉睫的疼痛有关，以及恐惧的个体差异如何 和/或性别会影响这些反应。此外，所提议的方法是 适应性强，随后可用于解决其他方面（感官和 情感）的痛苦经历。