DENTAL FEAR AND ANTICIPATION OF PAIN: IMAGING THE BRAIN

对牙科的恐惧和对疼痛的预期：大脑成像

• 批准号: 6634699
• 负责人: Margaret M Bradley
• 金额: $ 19.6万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-15 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6634699
• 关键词: brain circulation; brain imaging /visualization /scanning; brain mapping; clinical research; fear; gender difference; human subject; magnetic resonance imaging; psychophysiology

DESCRIPTION: The proposed experimental program is designed to assess changes in brain function that occur with fearful anticipation of a painful stimulus. Its principal aim is to determine the relationship between activity in specific brain structures (as defined by changes in regional blood flow), reports of fear arousal, and the electrocortical, visceral, and somatic responses that occur when expecting a painful stimulus. This research is driven by a motivational theory of human emotion that is founded on behavioral, psychophysiological, and neurophysiological research. The proposed studies are intended to explicate neural mechanisms that mediate fear of pain in normal humans, and furthermore, to examine possible individual differences in anticipation of pain between men and women, and between those who are low or high in dental fear. The specific aim of the proposed research is to map neural activation in the brain during fearful anticipation evoked by imminent painful stimulation, and to relate the obtained brain maps to psychophysiological patterns of fear reactivity. Three primary independent variables are assessed: 1) The type of anticipated stimulus (electric shock or nonpainful vibrotactile); 2) Dental fear level of the subject (low, high); and 3) Sex of the subject. Each of these eight studies (2 stimulus type x 2 fear groups x 2 sex) will be conducted once in the magnetic resonance imaging (MRI) context to assess functional brain activity, and once (with new participants) in a simulated MRI context to acquire autonomic, somatic, and central (i.e., EEG) physiological measures of anticipatory fear. The proposed research will address questions concerning the neural and psychophysiological organization of fear associated with imminent pain, as well as how individual differences in fear and/or sex affect these reactions. The proposed methodology is, furthermore, adaptable and can be used subsequently to address other facets (sensory and emotional) of the pain experience.

描述：拟议的实验计划旨在评估更改 令人恐惧地期待痛苦的刺激的大脑功能。它是 主要目的是确定特定活动的活动之间的关系 脑结构（由区域血流的变化定义） 恐惧唤醒，以及电型，内脏和躯体反应 当期望痛苦的刺激时发生。这项研究是由 基于行为的人类情感的动机理论， 心理生理学和神经生理学研究。拟议的研究是 旨在解释介导正常疼痛恐惧的神经机制 人类，此外，要研究可能的个体差异 男女之间对疼痛的期待，以及那些低点或 牙齿恐惧高。拟议研究的具体目的是绘制神经 在恐惧的期望中激活大脑的激活，迫在眉睫的痛苦引起 刺激，并将所获得的大脑图与心理生理相关联 恐惧反应的模式。评估了三个主要自变量： 1）预期刺激的类型（电击或非刺激 纤维状曲线）; 2）主题的牙齿恐惧水平（低，高）； 3）性 主题。这八项研究中的每一项（2种刺激X 2恐惧组x 2 性别）将在磁共振成像（MRI）上下文中进行一次 评估功能性大脑活动，一次（与新参与者） 模拟MRI上下文以获取自主，躯体和中心（即脑电图） 预期恐惧的生理措施。拟议的研究将解决 有关恐惧的神经和心理生理组织的问题 与迫在眉睫的疼痛以及恐惧中的个体差异有关 和/或性影响这些反应。此外，提出的方法是 适应性，随后可用于解决其他方面（感觉和 情感上的痛苦经历。