CORE--BIOSTATISTICS

核心--生物统计学

• 批准号: 6315990
• 负责人: Rita M. CANTOR
• 金额: $ 23.48万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6315990
• 关键词: biomedical facility; experimental designs; human population genetics; informatics; molecular biology information system; statistics /biometry

The Biostatistics Core will: 1) Provide advice on research design and statistical and genetic analyses, including sample size and power calculations. 2) Conduct statistical analyses of population and family data, including data transformations and adjustments. 3) Conduct genetic analyses of population and family data, including: a) two-point and multi-point linkage analyses of quantitative traits and qualitative disease status with genetic markers, and b) family and population based tests of association of disease status and quantitative traits with genetic markers. 4) Aid in the interpretation of the results of analyses to identify the next steps in a research plan. 5) Provide advice on experimental design and computer analyses of data generated by murine crosses. 6) Provide Bioinformatics support in the use of genome databases to aid in the construction of EST contigs and the identification of the coding regions on long rage sequences in databases.

生物统计学核心将：1）提供有关研究设计以及统计和遗传分析的建议，包括样本量和功率计算。 2）对人口和家庭数据进行统计分析，包括数据转换和调整。 3）对种群和家庭数据进行遗传分析，包括：a）定量性状和遗传标记的定量性状和定性疾病状态的两点和多点连锁分析，b）b）基于家庭和人群基于疾病状态和遗传标记的定量性状关联的测试。 4）帮助解释分析结果，以确定研究计划的下一步。 5）提供有关Murine Cross产生的数据的实验设计和计算机分析的建议。 6）在使用基因组数据库中提供生物信息学支持，以帮助构建EST重叠群，并在数据库中长期愤怒序列上识别编码区域。