Statistics, computation and data sharing core

统计、计算和数据共享核心

• 批准号: 9109007
• 负责人: Rita M. CANTOR
• 金额: $ 27.76万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9109007
• 关键词: Animals; Atherosclerosis; Biochemical; Collection; Computer Systems; Data; Data Analyses; Data Storage and Retrieval; Databases; Educational process of instructing; Epigenetic Process; Finland; Gene Expression; Genetic; Genomics; Human; Human Resources; Hybrids; Individual; Metabolic; Methods; Molecular Genetics; Mus; Nature; Output; Participant; Pathology; Physiology; Policies; Problem Solving; Procedures; Progress Reports; Quality Control; Research; Research Design; Retrieval; Role; SNP genotyping; Sampling; Services; Source; Techniques; Time; United States National Institutes of Health; Validation; base; cohort; data sharing; design; genetic approach; genomic data; human study; meetings; member; men; microbiome; novel; programs; skills; statistics; tool; trait

PROJECT SUMMARY Core C Core C, The Database, Computing and Statistics Core is central to the functions of the Program Project. It receives data from the Sequencing and Microbiome profiling Core and the Biochemical and Metabolic Services Core. An existing PPG database will be extended to receive the new data proposed for collection during the next cycle. There will be two sources of human and mouse data: the Hybrid Mouse Diversity Panel and the MetSim cohort of 10,000 men from Finland. These data will be cleaned, managed and maintained for the three PPG projects, and each will use data from both sources. Statistical genetics and genomic analyses will be designed, conducted and interpreted to satisfy the respective Specific Aims. The Core will interact with each projection a regular basis in order to conduct analyses in the most efficient and effective manner possible. It will be responsible for: 1) data storage, management and retrieval, 2) conducting or teaching project members to conduct routine statistical analyses such as comparing gene expression levels under different conditions, and 3) novel analyses that require study design, statistical analyses and interpretation of results. The Core will take responsibility for achieving compliance with any NIH policies regarding data submission to publicly available databases as the NIH rules evolve.

项目摘要 核心c 核心C，数据库，计算和统计核心是程序项目功能的核心。它 从测序和微生物组分析核心以及生化和代谢服务接收数据 核。将扩展现有的PPG数据库，以接收提出的新数据，以收集 下一个周期。将有两个人类和小鼠数据来源：混合小鼠多样性面板和 来自芬兰的10,000名男子的Metsim队列。这些数据将被清洁，管理和维护 三个PPG项目，每个项目都将使用来自两个来源的数据。统计遗传学和基因组分析将 设计，进行和解释以满足各自的特定目标。核心将与 每个投影都是定期的，以便以最有效的方式进行分析 可能的。它将负责：1）数据存储，管理和检索，2）进行或教学 项目成员进行常规统计分析，例如比较基因表达水平 不同条件和3）需要研究设计，统计分析和解释的新颖分析 结果。核心将负责实现有关数据的任何NIH政策 随着NIH规则的发展，向公开可用的数据库提交。