MEASURE SELF DIFFUSION COEFFICIENT OF ALL SPECIES PRESENT IN REVERSE MICELLE SYS

测量反胶束系统中存在的所有物种的自扩散系数

• 批准号: 6309164
• 负责人: RONALD R BURNETTE
• 金额: $ 0.75万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-15 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6309164
• 关键词: bioengineering /biomedical engineering; biological products; biomaterials; biomedical resource; biotechnology; drug /agent; nuclear magnetic resonance spectroscopy

Reverse micelles have a wide variety of applications. They can be used as microreactors to carry reactions of interest to the biotech industry and have numerous pharmaceutical applications relating to facilitating the delivery of drugs. However, for the full potential of these applications to be reached one must understand the environment that the solute experiences when placed inside a reverse micelle. In order to characterize this internal micelle environment, we are using 31P NMR to monitor the apparent pH of the water present inside the reverse micelles as a function of the water/surfactant ratios and oil/surfactant ratios. This information, when coupled with viscosity studies, allow us to delineate how the internal micelle environment is modified. We now propose to further characterize the reverse micelle, and its internal environment, by measuring the self-diffusion coefficients of all species present in the system through the use of Fourier Transform Pulsed Field Gradient Spin-Echo experiments.

反向胶束具有多种应用。 他们可以 用作微反应器，对生物技术产生感兴趣的反应 行业，并具有许多有关的药物应用 促进药物的递送。 但是，为了充分的潜力 在要达到的这些应用中，必须了解 将溶质放置在反向内部时会经历的环境 胶束。 为了表征这种内部胶束环境， 我们正在使用31p NMR监测存在的水的明显pH 在反向胶束内随水/表面活性剂的函数 比率和油/表面活性剂比率。 此信息与 粘度研究，允许我们描述内部胶束的方式 环境已修改。 我们现在建议进一步表征 反向胶束及其内部环境通过测量 系统中所有物种的自扩散系数 通过使用傅立叶变换脉冲场梯度旋转回波 实验。