ACUTE METABOLIC CONTROL & EXERCISE PERFORMANCE IN IDDM

急性代谢控制

• 批准号: 6305704
• 负责人: MICHAEL G CARLSON
• 金额: $ 0.06万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6305704
• 关键词: cardiovascular function; clinical research; exercise; human subject; insulin dependent diabetes mellitus; metabolism; performance; physical fitness

Exercise capacity and the cardiovascular and metabolic responses to acute exercise are impaired in poorly-controlled patients with insulin-dependent diabetes mellitus compared to well controlled IDDM subjects and nondiabetic controls matched for age, weight and level of habitual physical activity. Acute metabolic control via an overnight insulin infusion in poorly-controlled IDDM will improve but will not normalize exercise capacity nor the cardiovascular and metabolic responses to acute exercise.

与控制良好的IDDM受试者相比，胰岛素依赖性糖尿病的糖尿病患者的锻炼能力以及对急性运动的心血管和代谢反应受损，并且与年龄，体重和习惯性身体活动水平相匹配。 通过隔夜胰岛素输注不良的IDDM中的急性代谢控制将改善，但不会使运动能力正常化，也不会对急性运动的心血管和代谢反应进行标准化。