SLOW, LATENT & TEMPERATE VIRUS INFECTIONS

缓慢、潜伏

• 批准号: 6340325
• 负责人: THOMAS J ROWELL
• 金额: --
• 依托单位: UNIVERSITY OF LOUISIANA AT LAFAYETTE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-10-31 至 2003-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6340325
• 关键词: Ceboidea; Cercopithecidae; Macaca mulatta; Pan; Primates; animal breeding; animal care; animal colony; communicable disease control; communicable disease diagnosis; communicable disease transmission; disease /disorder model; latent virus infection; neurotropic virus; spongiform encephalopathy; virus infection mechanism

Research efforts concerning the viral study aspect of the contract are focused to determine the safety of the national blood supply in the United States and its military forces serving throughout the world; in the public health safety of animal derived food products; and the development and improvement of sensitive and specific diagnostic tests which will permit the introduction of therapeutic regimens that will either radiate the disease process or block the progression of the various infectious agents known, or suspected, to result in disease that has collectively been identified as Transmissible Spongiform Encephalopathies (TSEs). The contractor provides care, housing, and research support for nonhuman primates assigned to the Laboratory of Central Nervous System Studies, NINDS, in their effort to accomplish these goals. The contractor is responsible for monitoring nonhuman primates that have been, or will be, inoculated via various routes, with tissues known, or suspected to be, infected with one of the TSE agents, recording findings, and performing appropriate procedures to provide the Project Officer with animal samples for evaluation. The objective of the rhesus breeding aspect of the contract is to develop a colony of rhesus macaques capable of providing NINDS scientists with an uninterrupted supply of age-specific, disease-free macaques to continue on-going research projects and initiate new studies.

有关合同病毒研究方面的研究工作集中在确定美国国家血液供应的安全性及其在全球范围内服役；在动物衍生食品的公共卫生安全中；以及敏感和特定的诊断测试的开发和改进，这些测试将允许引入治疗方案，该治疗方案将辐射疾病过程，或阻止已知或怀疑的各种传染性剂的进展，从而导致疾病共同鉴定为可透射的spongiormans spongiorper concorporriper concorporriper conceporporrips（TSE）。 承包商为分配给中枢神经系统研究实验室Ninds实现这些目标的非人类灵长类动物提供护理，住房和研究支持。承包商负责监测已经或将通过各种途径接种的非人类灵长类动物，并以已知或怀疑的组织感染了其中一种TSE代理，记录发现，并执行适当的程序，以向项目官员提供动物样品进行评估。合同的恒河猴育种方面的目的是开发一个恒河猕猴的殖民地，能够为Ninds科学家提供不间断的特定年龄，无疾病的猕猴的供应，以继续正在进行的研究项目并启动新的研究。