ESTABLISH & MAINTAIN CHIMP BIOMEDICAL RES COLONY: VACCINE DVMT

建立

• 批准号: 7961236
• 负责人: THOMAS J ROWELL
• 金额: $ 20.61万
• 依托单位: UNIVERSITY OF LOUISIANA AT LAFAYETTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7961236
• 关键词: Accreditation; Acquired Immunodeficiency Syndrome; Animal Model; Behavioral Research; Biological Availability; Biomedical Research; Breeding; Commit; Communities; Computer Retrieval of Information on Scientific Projects Database; Conceptions; Databases; Drug Compounding; Drug Kinetics; Evaluation; Family; Female; Funding; Gene Pool; Genetic; Grant; HIV; HIV vaccine; Hepatitis A Virus; Hepatitis B Vaccines; Hepatitis C virus; Housing; Institutes; Institution; International; Laboratory Animals; Long-Term Care; Maintenance; Measures; Methods; Modeling; Monoclonal Antibodies; Pan Genus; Partner in relationship; Pharmacodynamics; Play; Population; Proteins; Protocols documentation; Research; Research Personnel; Resources; Respiratory syncytial virus; Role; Safety; Source; System; Testing; United States National Institutes of Health; Work; abstracting; animal care; data sharing; demographics; male; meetings; novel; offspring; programs; vaccine development

DESCRIPTION (provided by applicant): The biomedical and behavioral research community has long recognized the importance of chimpanzees (Pan troglodytes) as an animal model. Several measures have been instituted to stabilize populations, which are threatened in the wild. Most notably, Nations of the Convention on International Trade in Endangered Species (CITES) have specifically prohibited the importation of chimpanzees from the wild for research purposes; and the National Institutes of Health (NIH) created the `Chimpanzee Breeding and Research Program (CBRP). In 1986, the CBRP was created to insure a chimpanzee population in the United States for use in human health research. The University of Louisiana at Lafayette has been active in this endeavor since its conception. Chimpanzees continue to be essential models in the development of vaccines for hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis A virus (HAV), respiratory syncytial virus (RSV), and human immunodeficiency virus (HIV). In addition they play a critical role in the evaluation of thepharmacodynamics, pharmacokinetics, bioavailablity, safety, and efficacy of novel drug compounds, proteins and monoclonal antibodies. Specific aims of the application include the following: * To maintain capabilities to successfully breed (once the breeding moratorium has been lifted) and house chimpanzees in UL Lafayette-NIRC's CBRP AAALAC International-accredited colony * To conduct a longitudinal study to examine neurochemical and neuroendocrine correlates of aggressive and affiliative/social behavior and determine how position in the dominance hierarchy is associated with these parameters. * To collaborate and share data freely with the chimpanzee database grantees, investigators whose efforts would be supported by access to UL Lafayette's information and the ChiMP Coordinator, and to work with the ChiMP Advisory, Panel in developing long term plans for research use, breeding colony size, demographics, genetics, and long-term care. * To support national and international efforts to share biomedical research resources consistent with the National Institutes of Health's policy on Sharing of Model Organisms for Biomedical Research, and to enhance the development of and access to chimpanzee animal models critical to understanding human health needs consistent with NCRR's 2004-2008 Strategic Plan.

描述（由申请人提供）：生物医学和行为研究界长期以来已经认识到黑猩猩（Pan Troglodytes）作为动物模型的重要性。已经采取了一些措施来稳定人口，这些人口在野外受到威胁。最值得注意的是，《濒危物种国际贸易公约》（Cites）的国家特别禁止从野外进口黑猩猩出于研究目的；国立卫生研究院（NIH）创建了“黑猩猩育种与研究计划（CBRP）”。 1986年，创建了CBRP，以确保美国在人类健康研究中使用的黑猩猩种群。自从其受孕以来，路易斯安那大学拉斐特大学就一直活跃于这项工作。 黑猩猩继续是开发乙型肝炎病毒（HBV），丙型肝炎病毒（HCV），乙型肝炎A病毒（HAV），呼吸道促伴病毒（RSV）和人类免疫缺陷病毒（HIV）（HIV）的基本模型。此外，它们在评估新型药物化合物，蛋白质和单克隆抗体的评估中起着至关重要的作用。该应用程序的具体目的包括以下内容： *维持成功繁殖的能力（一旦取消了繁殖的暂停），并在Ul Lafayette-Nirc的CBRP AAAALAC国际认可的殖民地中居住了黑猩猩 *进行一项纵向研究，以检查侵略性和隶属性/社会行为的神经化学和神经内分泌相关性，并确定这些参数与主导地位层次结构中的位置如何相关。 *要与黑猩猩数据库受赠人自由合作并共享数据，调查人员将通过获取UL Lafayette的信息和黑猩猩协调员的努力来支持，并与Chimp Advisory，与小组合作，制定研究使用，繁殖菌落大小，人口统计学，遗传学和长期护理的长期计划。 *支持国家和国际努力共享与国家卫生研究院为生物医学研究共享模型生物的政策一致的生物医学研究资源，并增强了与理解NCRR 2004-2008战略计划一致的人类健康需求至关重要的黑猩猩动物模型的发展和获取。