UCLA-CDU CFAR

加州大学洛杉矶分校-CDU CFAR

• 批准号: 10458369
• 负责人: Judith S. Currier
• 金额: $ 300.56万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-08 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10458369
• 关键词: AIDS prevention; AIDS/HIV problem; Accreditation; Acquired Immunodeficiency Syndrome; Address; Animal Model; Area; Award; Behavioral; Biological Assay; California; Clinic; Clinical; Clinical Informatics; Clinical Laboratory Improvement Amendments; Clinical Research; Clinical Sciences; Clinics and Hospitals; Collaborations; Communities; County; Data; Development; Disease; Disease remission; Ensure; Epidemic; Equipment; Faculty; Funding; Goals; Grant; HIV; HIV Infections; Healthcare Systems; Incubators; Infection prevention; Infrastructure; Institutes; Institution; Interdisciplinary Study; Laboratories; Leadership; Link; Los Angeles; Medical center; Mentors; Mission; Morbidity - disease rate; Neighborhoods; Participant; Pathogenesis; Persons; Pilot Projects; Policies; Population; Procedures; Provider; Public Health Informatics; Registries; Regulation; Research; Research Activity; Research Personnel; Resources; Sampling; Science; Scientist; Services; Shapes; Site; Structure; Talents; Techniques; Training; Training Activity; Translational Research; United States National Institutes of Health; Universities; Ursidae Family; base; behavioral study; biobank; career; community based participatory research; community based research; community engagement; cost effective; design; gene therapy; health equity; humanized mouse; meetings; member; metropolitan; multidisciplinary; next generation; prevent; programs; recruit; research study; social; substance use; success; symposium; working group

Overall: Project Summary/Abstract: This application is a resubmission for a new CFAR that is a partnership between UCLA and CDU. Our overarching goal is to create a nimble multi-institutional infrastructure that promotes equity and will connect and support investigators affiliated with both institutions to advance critical HIV science. The UCLA-CDU CFAR will strengthen and amplify the impact of existing research activities and launch new partnerships across Los Angeles and globally through our focus on three themes: we will STOP HIV by preventing new HIV infections (Prevention), reducing morbidity among people living with HIV (Treatment) and developing strategies for eradication (ART-free Remission). This grant will fund AIDS-related activities and programs conducted by investigators at UCLA, CDU and our Affiliated institutions, which include Harbor-UCLA Medical Center in Torrance; the UCLA CARE Clinic and the VA Greater Los Angeles Healthcare System in Westwood; the UCLA Vine Street Clinic in West Hollywood; and the Drew CARES, the CDU PUSH coalition and the MLK OASIS Clinic at CDU. These facilities are at ground zero for the AIDS epidemic in Los Angeles County, with the greatest number of persons living with HIV residing in the neighborhoods directly served by our hospitals and clinics. In addition to the facilities and programs based in Los Angeles, researchers at UCLA and CDU have extensive partnerships with HIV programs around the globe that are aimed at building global capacity. The CFAR will enhance our ability to deliver research at the interface of community by reaching communities most in need and by bringing to bear the talent of CDU and UCLA researchers to address problems from a multi-disciplinary perspective while mentoring the next generation who better reflect the diversity of communities being served. The overall organization of the UCLA-CDU CFAR will allow us to efficiently and effectively manage AIDS research activities by harnessing the diverse expertise in our CFAR, and by including linkages to community- based clinician investigators and communities. The action plan for the first year of requested support includes 6 cores and 1 scientific working group (SWG): the Administrative Core, Developmental Core, Centralized Laboratory Support Core, Humanized Mouse and Gene Therapy Core, Community Engagement and Clinical Informatics Core, Clinical Science Core, and a Translational Research in Substance Use SWG. RELEVANCE: Research into the pathogenesis, treatment and social aspects of HIV disease is required to end the epidemic. The UCLA-CDU CFAR seeks to catalyze and expand HIV research by providing the infrastructure to connect, support and enhance the capacity of investigators affiliated with UCLA and CDU. This will be accomplished by stimulating the conduct and dissemination of high impact multidisciplinary research aimed at the NIH priorities of preventing new HIV infections (Prevention), reducing morbidity among people living with HIV (Treatment) and developing strategies for eradication (ART-free Remission).

总体：项目摘要/摘要：此应用程序是新的CFAR的重新提交，该CFAR是合伙企业 在UCLA和CDU之间。我们的总体目标是创建一个敏捷的多机构基础架构 促进股权，并将与两个机构有联系的调查人员联系，以推动关键的艾滋病毒 科学。 UCLA-CDU CFAR将加强和扩大现有研究活动的影响并启动 通过我们关注三个主题的洛杉矶和全球的新伙伴关系：我们将阻止艾滋病毒 防止新的艾滋病毒感染（预防），降低艾滋病毒（治疗）和 制定根除策略（无艺术缓解）。该赠款将资助与艾滋病相关的活动，并 加州大学洛杉矶分校，CDU和我们的附属机构的调查人员开展的计划，其中包括Harbor-Ucla 托伦斯的医疗中心； UCLA护理诊所和VA大洛杉矶医疗保健系统 韦斯特伍德；西好莱坞的UCLA Vine Street诊所；以及Drew Cares，CDU推动联盟和 CDU的MLK OASIS诊所。这些设施在洛杉矶县的艾滋病流行病的地面为零 居住在艾滋病毒的人数最多的人居住在我们医院直接服务的社区中 和诊所。除了位于洛杉矶的设施和计划外，加州大学洛杉矶分校和CDU的研究人员还 旨在建立全球能力的全球艾滋病毒计划的广泛合作伙伴关系。 CFAR 通过吸引最需要的社区，将增强我们在社区界面进行研究的能力 并聘请CDU和UCLA研究人员的才华来解决多学科的问题 在指导下一代，他们更好地反映了所服务的社区的多样性。 UCLA-CDU CFAR的整体组织将使我们能够有效地管理艾滋病 通过利用CFAR的多样专业知识以及与社区的联系来利用研究活动 - 基于临床医生的研究人员和社区。要求支持第一年的行动计划包括 6个核心和1个科学工作组（SWG）：行政核心，发展核心，集中式 实验室支持核心，人性化的老鼠和基因疗法核心，社区参与和临床 信息学核心，临床科学核心以及SWG的物质使用的翻译研究。关联： 需要研究HIV疾病的发病机理，治疗和社会方面才能结束流行病。 UCLA-CDU CFAR试图通过提供连接基础设施来催化和扩大HIV研究 支持并增强与UCLA和CDU相关的研究人员的能力。这将通过 刺激针对NIH优先事项的高影响力多学科研究的行为和传播 预防新的艾滋病毒感染（预防），降低艾滋病毒（治疗）和 制定根除策略（无艺术缓解）。