FACILITY FOR NON-HUMAN PRIMATES IN INFECTIOUS DIS RES

传染性疾病治疗中的非人类灵长类动物设施

• 批准号: 3725792
• 负责人: RICHARD BRADBURY
• 金额: $ 50.42万
• 依托单位: BIOQUAL, INC.
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-01-01 至 1994-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3725792
• 关键词: Aotus; Ceboidea; Cercopithecidae; Macaca mulatta; Pneumovirus vaccine; Primates; Rotavirus; Saimiri; animal colony; biomedical facility; biopsy; cell bank /registry; enteritis; ferrets; hyperbaric chamber; influenza; lymph nodes; respiratory disorder; respiratory infections; respiratory syncytial virus; serotyping

The objective of this program is to maintain non-human primates and other small animals in biohazard containment facilities for studies of selected respiratory tract and enteric disease. In addition, many technical procedures will be performed on the animals. Testing of various reassortant influenza viruses, human respiratory syncytial viruses and rotaviruses will be done in squirrel, owl, patas, rhesus, and African Green monkeys, and possibly ferrets. Studies with respiratory tract infections will, particularly, be focused on testing of candidate vaccine strains and will involve from 4 to 20 animals per study. Individual studies will likely not exceed two months in duration and up to 8 studies will be performed each year. The technical and professional staff of SEMA will perform the experimental protocols as provided by the Project Officer. This will include inoculating the primates with viral material provided by the Project Officer, collecting blood and tissue samples, performing physical examinations, and other experimental procedures such as exploratory laparotomies and lymph node biopsies. For most of the studies, it is anticipated that SEMA will perform nasal and throat swabs, tracheal lavages, intratracheal inoculations, radiographs and clinical observations. For a typical 20 animal influenza study; 20 radiographs, 20 tracheal inoculations, 600 nasal and throat swabs, 120 tracheal lavages and 100 blood samples will be performed over a 28 to 56 day period.

该计划的目标是维持非人类灵长类动物和 生物危害控制设施中的其他小动物用于研究 选择呼吸道和肠道疾病。 此外，许多 将对动物进行技术程序。 测试 各种重配流感病毒、人类呼吸道合胞体 病毒和轮状病毒将在松鼠、猫头鹰、帕塔斯、恒河猴、 和非洲绿猴，可能还有雪貂。 呼吸道感染的研究将特别集中 对候选疫苗株进行测试，将涉及 4 至 20 个 每项研究的动物。 个别研究可能不会超过两个月 每年将进行多达 8 项研究。 SEMA 的技术和专业人员将执行 实验方案由项目官员提供。 这将 包括给灵长类动物接种由 项目官员，采集血液和组织样本，执行 身体检查和其他实验程序，例如 剖腹探查术和淋巴结活检。 对于大多数 研究，预计 SEMA 将进行鼻腔和咽喉 拭子、气管灌洗、气管内接种、X光片和 临床观察。 针对典型的 20 只动物流感研究； 20 X 线照片、20 次气管接种、600 份鼻咽拭子、120 份 将在 28 至 56 天内进行气管灌洗和 100 份血样 日期间。