ACTH STIMULATION TEST TO EVALUATE ADEQUACY OF HPA AXIS

ACTH 刺激试验评估 HPA 轴的充足性

• 批准号: 6264128
• 负责人: ROY E WEISS
• 金额: $ 3.28万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264128
• 关键词: Cushing's syndrome; adenoma; adrenocorticotropic hormone; clinical research; diagnosis quality /standard; endocrine disorder diagnosis; endocrine surgery; hormone biosynthesis; human subject; hypothalamic pituitary adrenal axis; medical complication; postoperative state

This study will compare the sensitivity of the 1 mcg ACTH stimulation test to gold standard insulin tolerance testing in determining hypothalamic- pituitary-adrenal recovery in patients status post surgery for Cushing's syndrome secondary to pituitary or adrenal adenomas. These two tests will also be compared in patients with suspected hypopituitarism, to determine the ACTH test's sensitivity in screening for dysfunction. If the ACTH test has sufficient sensitivity, it could replace the insulin test in clinical practice.

本研究将比较 1 mcg ACTH 刺激试验与金标准胰岛素耐受试验的敏感性，以确定继发于垂体或肾上腺腺瘤的库欣综合征术后患者下丘脑-垂体-肾上腺的恢复情况。 这两项测试还将在疑似垂体功能减退症患者中进行比较，以确定 ACTH 测试在筛查功能障碍方面的敏感性。 如果ACTH测试有足够的敏感性，它可以在临床实践中取代胰岛素测试。