Hemodynamics of the Portal Venous System in Normal Volunteers using MRI

使用 MRI 观察正常志愿者门静脉系统的血流动力学

• 批准号: 6227865
• 负责人: Elizabeth C. Jones
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6227865
• 关键词: bioimaging /biomedical imaging; clinical research; eating; fasting; hemodynamics; human subject; magnetic resonance imaging; mathematical model; model design /development; portal vein; volunteer

There are three components of the study: technical development to define the imaging protocol; conduct the observational study of blood flow patterns in study subjects; and define the anatomy and flow parameters for construction of flow models. The development of the principal imaging protocol is complete; the portal anatomy and flow patterns can be reproducibly imaged. During the period of technical development, we have observed evidence of the phenomenon of blood streaming, which is the central hypothesis of our study. The observational study of subjects after fasting and after a meal began in July 1999. Preliminary anatomic and flow data have been collected for model construction; a preliminary model has been constructed. We expect to refine the model and initiate the flow studies within the next few months and continue the study.

这项研究的三个组成部分是：定义成像协议的技术开发；进行研究对象中血流模式的观察性研究；并定义用于构建流模型的解剖学和流参数。主要成像协议的开发已完成；可以重现的门户解剖结构和流动模式。在技​​术发展期间，我们观察到了血液流现象的证据，这是我们研究的中心假设。禁食后和饭后的受试者的观察性研究于1999年7月开始。已收集了用于模型构建的初步解剖和流量数据。已经构建了初步模型。我们希望在接下来的几个月内完善模型并启动流量研究，并继续研究。