Translational Development of Photon-Counting CT Imaging

光子计数 CT 成像的转化发展

• 批准号: 10682303
• 负责人: Elizabeth C. Jones
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682303
• 关键词: Abdomen; Angiography; Area; Bismuth; Blood Vessels; Calcium; Cerebrum; Clinical; Collaborations; Computed Tomography Scanners; Contrast Media; Cooperative Research and Development Agreement; Coronary artery; Development; Diagnostic Imaging; Discrimination; Dose; Head and neck structure; Image; Image Analysis; Imaging Techniques; Investigation; Kidney; Lesion; Low Dose Radiation; Lung; Measures; Medical; Medical Imaging; Methods; National Heart, Lung, and Blood Institute; Noise; Patients; Pelvis; Penetration; Performance; Photons; Physics; Research; Resolution; Roentgen Rays; Science; Scientist; Site; System; Techniques; Translations; Tube; United States National Institutes of Health; Universities; Visualization; X-Ray Computed Tomography; base; bone imaging; clinical center; clinical imaging; computed tomography screening; contrast enhanced computed tomography; density; detector; imaging capabilities; imaging modality; innovation; lung imaging; noninvasive diagnosis; radiological imaging; soft tissue; spectrograph

The investigational Photon-Counting CT scanner has been installed in the Radiology and Imaging Sciences Department at NIH Clinical Center since 2015. Over the last 5 years, the research team conducted comparisons of the clinical quality of the Photon-counting vs conventional images and was not able to detect any difference between these techniques in standard clinical imaging applications such as abdominal pelvic contrast enhanced CT, low dose lung screening CT, computed tomographic angiography (CTA) of the abdomen and head and neck, and cerebral CT. In 2018 the research team changed in membership and redirected focus toward clinical task-based medical physics assessments of scanner performance in collaboration with Duke University Medical Physics Department. These task based assessments, include comparison of soft tissue measures of comparison typically in the abdomen, explorations of impact of lowering to very low radiation dose imaging, vascular imaging and evaluation of higher resolution capabilities applied to imaging of the lung and bone. An example of clinical imaging tasks is the optimization of vascular imaging of coronary arteries. In this study the team collaborated with scientists from NHLBI to characterize the capabilities of photon counting to distinguish between high density iodinated contrast and adjacent calcium in coronary artery phantoms. The research team is currently focused on three areas: optimization of scanner acquisition and post-processing parameters for specific clinical tasks, utility of photon-counting CT and post-processing techniques for the visualization and characterization of kidney lesions, and leveraging multi-energy (spectral) imaging capabilities. These capabilities may be used to image innovative contrast agents such as Bismuth.

The investigational Photon-Counting CT scanner has been installed in the Radiology and Imaging Sciences Department at NIH Clinical Center since 2015. Over the last 5 years, the research team conducted comparisons of the clinical quality of the Photon-counting vs conventional images and was not able to detect any difference between these techniques in standard clinical imaging applications such as abdominal pelvic contrast enhanced CT, low dose lung screening CT,腹部和头颈的计算机断层扫描（CTA），以及大脑CT。 2018年，研究小组在与杜克大学医学物理系合作的基于临床任务的医学物理学评估方面改变了会员资格，并将重点转向了基于临床任务的医学物理评估。这些基于任务的评估包括通常在腹部比较的软组织测量，降低对非常低辐射剂量成像的影响的探索，血管成像以及用于肺部成像的较高分辨率功能的评估。 临床成像任务的一个例子是优化冠状动脉的血管成像。 在这项研究中，该团队与NHLBI的科学家合作，以表征光子计数的能力，以区分冠状动脉幻影中高密度碘化对比度和相邻钙。 该研究团队目前专注于三个领域：针对特定临床任务的扫描仪获取和后处理参数，光子计数CT的实用性以及用于可视化和表征肾脏病变的后处理技术，以及利用多能（光谱）成像能力。这些功能可用于图像创新的对比剂，例如Bismuth。