CROSS LINKER:BIOMACROMOLEC DIALKYL SULFONYLPROPENYLAMINE: HEMOGLOBIN BLOOD SUBST

交联剂：生物大分子二烷基磺酰丙烯胺：血红蛋白血液底物

• 批准号: 6122954
• 负责人: EARL DOOMES
• 金额: $ 7.57万
• 依托单位: SOUTHERN UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6122954
• 关键词: biological products; biomaterials; drug /agent; hematology; minority institution research support; nuclear magnetic resonance spectroscopy; proteins; spectrometry

The specific aims of this proposal are directed toward development of highly selective organic cross-linking reagents for hemoglobins that would lead to modified hemoglobins that could be used as blood substitutes. The effectiveness of the organic cross-linking reagents is expected to be a complex function of "linker" length, chemical reactivity, and solubility properties of the agent. The title compounds constitute a new class of bifunctional organic reagents that are expected to show a high level of selectivity toward ammonium groups in proteins. The structural design of the reagents allows us to alter chemical properties and molecular dimensions in a systematic way.

该提议的具体目的是针对发展的 血红蛋白的高度选择性有机交联试剂 这将导致可以用作血液的改性血红蛋白 替代品。 有机交联试剂的有效性 预计将是“接头”长度，化学的复杂功能 试剂的反应性和溶解度。 标题化合物构成了新的双功能有机类 预计将显示出高度选择性的试剂 蛋白质中的铵基。 试剂的结构设计 允许我们改变化学性质和分子尺寸 系统的方式。