STRUCTURAL EVOLUTION OF PRIMATE BRAIN

灵长类动物大脑的结构进化

• 批准号: 6277493
• 负责人: Thomas R. Insel
• 金额: $ 4.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277493
• 关键词: Mammalia; Primates; cognition; magnetic resonance imaging; nervous system; psychology; sociology /anthropology; technology /technique

The goal of this project is to establish a database for comparative neuroanatomy of primates using high resolution magnetic resonance imaging (MRI). Thus far, 44 animals have been scanned, including representatives of every species listed above and all of these scans have been reconstructed to provide surface rendering and volumetric measures of whole brain and whole cerebellum. A technique for gray matter/white matter segmentation has been developed and applied to analyze these volumes separately. Results to date indicate 1) a decrease in relative cerebellar volume in humans compared to apes; 2) a decrease in relative corpus callosum size in the human brain; and 3) marked regional expansion of neocortex in the human and ape brains as measured by gyrification. These studies provide the first MRI database for studies of comparative primate brain evolution and should yield novel insights into differences between human and non-human primate neuroanatomy.

该项目的目标是建立一个数据库 使用高分辨率磁力对灵长类动物进行比较神经解剖学 磁共振成像（MRI）。 到目前为止，已经扫描了 44 只动物， 包括上面列出的每个物种的代表以及所有 这些扫描已被重建以提供表面渲染和 全脑和整个小脑的体积测量。 一项技术 已经开发出用于灰质/白质分割的 用于分别分析这些卷。 迄今为止的结果表明 1）与人类相比，人类的相对小脑体积减少 猿类； 2）人类胼胝体相对尺寸减小 脑; 3）人类新皮质的显着区域扩张 通过回转测量的猿脑。 这些研究提供了 第一个用于研究比较灵长类大脑进化的 MRI 数据库 并且应该对人类和人类之间的差异产生新的见解 非人类灵长类动物神经解剖学。