AGING & STRESS IN FEMALE PRIMATES

老化

• 批准号: 6116282
• 负责人: TP GORDON
• 金额: $ 8.4万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116282
• 关键词: Mammalia; behavioral /social science research tag; cognition; psychology

Evidence supporting a relationship between stress and reveals increased rates of dexamethasone resistance and basal hypersecretion of glucocorticoids in normal elderly humans. This relationship has been revealed in clinical studies which are highly relevant, however this approach does not permit the specificity of variables or degree of control which may be obtained using animal models. Comparing older and prime aged female rhesus monkeys in a series of studies has provided a specific test of hypotheses regarding 1) the ability of old females to adapt to stress, 2) the effect of stress on the pituitary-adrenocortical axis and the immune system (using functional measures), 3) the effect of social companionship and reactivity in modulating stress and 4) the effect of HRT on immune system measures in ovariectomized females. During this past year studies have been directed toward assessment of factors that have been shown to predictive of immune perturbation in aging in dividual s. These experiments demonstrated differences in stress reactivity, as indicated by changes in immune function, between prime and old age rhesus monkeys, confirming the primary hypothesis. This observation is consistent with a literature suggesting that aging is characterized by a decreased ability of individuals to adapt to stress, a decrement that is linked is linked to hypothalamic-pituitary-adrenal axis dysregulation. FUNDING NIH / AG13722 $133,704 12/01/1996 - 11/30/99 PUBLICATIONS None P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center

支持压力与揭示压力之间关系的证据 地塞米松耐药性和基础突出分泌的发生率提高 正常老年人的糖皮质激素。 这种关系有 在高度相关的临床研究中揭示了 这种方法不允许变量或程度的特异性 可以使用动物模型获得的控制。 比较较老 一系列研究中的主要老年雌性恒河猴具有 提供了有关假设的特定测试，关于1）旧的能力 女性适应压力，2）压力对 垂体 - 肾上腺皮质轴和免疫系统（使用功能 措施），3）社会陪伴和反应性的影响 调节应力和4）HRT对免疫系统测量的影响 在卵巢切除的女性中。 在过去的一年中，研究是 针对已证明的因素的评估 预测分裂中衰老中的免疫扰动。这些 实验表明压力反应性的差异为 免疫功能的变化指示 恒河猴，证实了主要假设。 这个观察结果 与表明衰老的文献一致 通过降低个人适应压力的能力，减少了 链接与下丘脑 - 垂体 - 肾上腺轴链接 失调。 资金NIH/AG13722 $ 133,704 12/01/1996-11/30/99 出版物无P51RR00165-38 1/1/98-12/31/98 Yerkes地区 灵长类动物研究中心