DEVELOPMENT OF DNA VACCINES FOR CONTRACEPTION

用于避孕的 DNA 疫苗的开发

• 批准号: 6277482
• 负责人: KENNETH G GOULD
• 金额: $ 3.36万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277482
• 关键词: Mammalia; Primates; clinical research; endocrine gland /system; growth /development; reproductive system; women's health

This is a pilot study to attempt to immunize male and female macaques to an androgen dependent, epididymis specific protein associated with sperm function. The rationale is that immunization of the female, with secretion of antibody into the female reproductive tract, will interfere with fertilization. The DNA associated with expression of EP2 was used as antigen, administered intradermally using a gene gun. Of eight females injected, two demonstrated evidence of antibody formation. Although possible delayed, pregnancy was not inhibited. Future work will be directed to optimization of the vaccination schedule and alteration of the route of DNA administration in order to maximize antibody production prior to reproductive challenge.

这是一项试图免疫男性和女性的试点研究 猕猴依赖于雄激素，附睾特异性蛋白 与精子功能相关。 理由是 雌性分泌为雌性生殖 区域将干扰受精。 与 EP2的表达用作抗原，在皮内给药 使用基因枪。 在注射的八名女性中，有两名证明 抗体形成的证据。 虽然可能延迟，但怀孕 没有被抑制。 未来的工作将针对优化 DNA途径的疫苗接种时间表和改变 为了在之前最大化抗体产生 生殖挑战。