SPECIFIC IMMUNITY DEVELOPMENT IN HUMAN NEWBORNS

人类新生儿的特异性免疫发育

• 批准号: 6276159
• 负责人: Anthony R. Hayward
• 金额: $ 1.86万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276159
• 关键词: T lymphocyte; active immunization; blood transfusion; cellular immunity; clinical research; developmental immunology; human subject; leukocyte activation disorder; microorganism immunology; neonatal intensive care; newborn human (0-6 weeks); premature infant human

Premature infants who survive several weeks of intensive care subsequently experience morbidity from recurrent infections, such as RSV infections of the respiratory tract. Our data suggest that these infants are poor at making T cell responses following immunization. We will analyze the T cell subset phenotypes in infants receiving blood transfusion compared with untransfused controls.

早产的婴儿在重症监护中生存几周 随后经历了复发感染的发病率，例如 呼吸道的RSV感染。 我们的数据表明这些 婴儿在免疫后做出T细胞反应的差。 我们 将分析接受血液的婴儿的T细胞子集表型 输血与未转移的对照相比。