SPECIFIC IMMUNITY DEVELOPMENT IN HUMAN NEWBORNS

人类新生儿的特异性免疫发育

• 批准号: 6246041
• 负责人: Anthony R. Hayward
• 金额: $ 1.71万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246041
• 关键词: T lymphocyte; active immunization; blood transfusion; cellular immunity; clinical research; developmental immunology; human subject; leukocyte activation disorder; microorganism immunology; neonatal intensive care; newborn human (0-6 weeks); premature infant human; T lymphocyte; active immunization; blood transfusion; cellular immunity; clinical research; developmental immunology; human subject; leukocyte activation disorder; microorganism immunology; neonatal intensive care; newborn human (0-6 weeks); premature infant human

Premature infants who survive several weeks of intensive care subsequently experience morbidity from recurrent infections, such as RSV infections of the respiratory tract. Our data suggest that these infants are poor at making T cell responses following immunization. We will analyze the T cell subset phenotypes in infants receiving blood transfusion compared with untransfused controls.

过早在重症监护几周内生存的早产儿 经历复发感染的发病率，例如RSV感染 呼吸道。 我们的数据表明，这些婴儿很差 免疫后产生T细胞反应。 我们将分析t 接受输血的婴儿的细胞子集表型相比 带有未转运的控件。